SCHEMBL7304146

SCHEMBL7304146

COC(=O)[C@@H]1CCCN1C(=O)[C@H]1NCC(=S)C1C(=O)CCCCCC1CCc2cc(C)c(C)cc2C1

nearest known ligand 0.33

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.33
RAB9A P51151 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
SLC8A1 P32418 1/20 0.31
AVPR2 P30518 1/20 0.31
CNR2 P34972 1/20 0.30
PREP P48147 4/20 0.30
FKBP1A P62942 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7304152 0.87 LMNA (0.34) LMNARAB9ASMN1; SMN2SLC8A1AVPR2
SCHEMBL7301966 0.76 HTR1A (0.34) FKBP1A
SCHEMBL9171673 0.75 GBA1 (0.40) SLC8A1PREP
SCHEMBL9049004 0.75 GBA1 (0.40) SLC8A1PREP
SCHEMBL9048083 0.75 PREP (0.40) PREP
SCHEMBL9049237 0.75 PREP (0.40) PREP
SCHEMBL7296495 0.74 DPP4 (0.41)
SCHEMBL9047127 0.73 PREP (0.41) PREP
SCHEMBL9049419 0.73 PREP (0.39) SLC8A1PREP
SCHEMBL9049657 0.73 PREP (0.39) SLC8A1PREP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0372484-B1 Condensed benzene derivative ZERIA PHARM CO LTD (JP) 1994-10-26 EP disclosed
US-5028604-A Cognition Activators ZERIA PHARMACEUTICAL CO., LTD. (JP) 1991-07-02 US disclosed
EP-0372484-A2 Condensed benzene derivative ZERIA PHARMACEUTICAL CO., LTD. (JP) 1990-06-13 EP disclosed