SCHEMBL7304152

SCHEMBL7304152

COC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NCCC1C(=O)CCCCCC1CCc2cc(C)c(C)cc2C1

nearest known ligand 0.34

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.34
RAB9A P51151 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
AVPR2 P30518 1/20 0.32
CNR2 P34972 2/20 0.31
PREP P48147 4/20 0.31
FKBP1A P62942 3/20 0.31
ALDH1A1 P00352 3/20 0.31
CYP3A4 P08684 1/20 0.31
TSHR P16473 1/20 0.31
PKM P14618 1/20 0.31
PEPD P12955 1/20 0.31
XPNPEP1 Q9NQW7 1/20 0.31
SLC8A1 P32418 1/20 0.31
CNR1 P21554 1/20 0.30
GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7304146 0.87 LMNA (0.33) LMNARAB9ASMN1; SMN2AVPR2CNR2
SCHEMBL7298452 0.74 LMNA (0.41) LMNARAB9ASMN1; SMN2PREPFKBP1A
SCHEMBL7303639 0.69 CPT2 (0.31)
SCHEMBL7302899 0.68 PREP (0.38) PREPFKBP1AALDH1A1CYP3A4TSHR
SCHEMBL9049697 0.67 PREP (0.38) PREP
SCHEMBL9049692 0.67 PREP (0.38) PREP
SCHEMBL7440417 0.67 HTR1A (0.34) PREP
SCHEMBL7304031 0.67 DPP4 (0.35) SMN1; SMN2PREPALDH1A1
SCHEMBL9049537 0.66 PREP (0.57) PREP
SCHEMBL9050167 0.66 PREP (0.57) PREP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0372484-B1 Condensed benzene derivative ZERIA PHARM CO LTD (JP) 1994-10-26 EP disclosed
US-5028604-A Cognition Activators ZERIA PHARMACEUTICAL CO., LTD. (JP) 1991-07-02 US disclosed
EP-0372484-A2 Condensed benzene derivative ZERIA PHARMACEUTICAL CO., LTD. (JP) 1990-06-13 EP disclosed