Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 10/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 10/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 2/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.41 |
| ▸ | TMPRSS15 | P98073 | 4/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7299599 | 0.88 | ITGB3 (0.51) | ITGB3ITGA2BACEPRSS1TMPRSS15 | |
| SCHEMBL9742835 | 0.88 | ITGB3 (0.51) | ITGB3ITGA2BACEPRSS1TMPRSS15 | |
| SCHEMBL7331194 | 0.85 | BACE1 (0.44) | ACEPRSS1TMPRSS15 | |
| Trifluoroacetic Acid SCHEMBL3040708 | 0.84 | ITGB3 (0.50) | ITGB3ITGA2BACEPRSS1TMPRSS15 | |
| SCHEMBL7304862 | 0.83 | ITGB3 (0.51) | ITGB3ITGA2BPRSS1TMPRSS15 | |
| SCHEMBL7303040 | 0.82 | ITGB3 (0.55) | ITGB3ITGA2BFOLH1 | |
| SCHEMBL13744704 | 0.81 | ITGB3 (0.48) | ITGB3ITGA2BMMP2MMP7MMP9 | |
| SCHEMBL7298590 | 0.81 | PRSS1 (0.47) | ITGB3ITGA2BACEPRSS1TMPRSS15 | |
| SCHEMBL13716864 | 0.79 | ACE (0.49) | ACEFOLH1 | |
| SCHEMBL13716830 | 0.79 | L3MBTL1 (0.56) | ITGB3ITGA2BMMP2MMP7MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445796-B1 | Derivatives of acetic acid containing peptide bonds | HOFFMANN LA ROCHE (CH) | 1998-06-17 | — | — | EP | claimed |
| US-5430024-A | Peptides bearing N-terminal amidino moieties and their use as inhibitors of platelet aggregation | HOFFMANN-LA ROCHE INC. (US) | 1995-07-04 | — | — | US | claimed |
| EP-0445796-A2 | Derivatives of acetic acid | F. HOFFMANN-LA ROCHE AG (CH) | 1991-09-11 | — | — | EP | claimed |
| EP-0445796-B1 | Derivatives of acetic acid containing peptide bonds | HOFFMANN LA ROCHE (CH) | 1998-06-17 | — | — | EP | disclosed |
| US-5430024-A | Peptides bearing N-terminal amidino moieties and their use as inhibitors of platelet aggregation | HOFFMANN-LA ROCHE INC. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5273982-A | An amidinoaryleneamidoalkylpiperazinyleneacetic acid | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0445796-A2 | Derivatives of acetic acid | F. HOFFMANN-LA ROCHE AG (CH) | 1991-09-11 | — | — | EP | disclosed |