Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPFFR1 | Q9GZQ6 | 3/20 | 0.59 |
| ▸ | NPFFR2 | Q9Y5X5 | 3/20 | 0.59 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | CACNA1G | O43497 | 5/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304290 | 0.84 | NPFFR1 (0.53) | NPFFR1NPFFR2BCHEACHECACNA1G | |
| SCHEMBL3937184 | 0.83 | NPFFR1 (0.66) | NPFFR1NPFFR2CACNA1GOPRL1POLB | |
| SCHEMBL2842737 | 0.83 | NPFFR1 (0.69) | NPFFR1NPFFR2CACNA1GOPRL1POLB | |
| SCHEMBL2472050 | 0.80 | LMNA (0.67) | NPFFR1NPFFR2ACHECACNA1GOPRL1 | |
| SCHEMBL7305720 | 0.80 | ALDH1A1 (0.48) | OPRL1POLBSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL27566058 | 0.78 | NPFFR1 (0.60) | NPFFR1NPFFR2CACNA1GOPRL1POLB | |
| SCHEMBL7306023 | 0.78 | CACNA1G (0.52) | NPFFR1NPFFR2BCHEACHECACNA1G | |
| SCHEMBL13897424 | 0.78 | NPFFR1 (0.62) | NPFFR1NPFFR2CACNA1GOPRL1POLB | |
| SCHEMBL4631201 | 0.77 | BCHE (0.52) | NPFFR1NPFFR2BCHEACHECACNA1G | |
| SCHEMBL13320953 | 0.77 | NPFFR1 (0.62) | NPFFR1NPFFR2CACNA1GOPRL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294537-B1 | NEUROKININS USED FOR TREATMENT OF DISEASES | SANOFI-SYNTHELABO (FR) | 2001-09-25 | — | — | US | disclosed |
| US-6124316-A | ACTIVE DRUG TREATING PSYCHIATRIC DISEASES, DISEASES OF PSYCHOSOMATIC ORIGIN, OF HYPERTENSION AND, NERVOUS SYSTEM DISORDERS | SANOFI (FR) | 2000-09-26 | — | — | US | disclosed |
| US-5942523-A | NOVEL PIPERIDINE DERIVATIVES WHOSE SPECIFIC STRUCTURE INCLUDES AT POSITION 1 AN ALKYL CHAIN HAVING A 3,4-DICHLOROPHENYL GROUP ATTACHED; HIGH SELECTIVITY TO THE NK3 RECEPTOR; UNIT DOSAGE FORM; TREATING PSYCHIATRIC DISEASES | SANOFI (FR) | 1999-08-24 | — | — | US | disclosed |
| US-5741910-A | PIPERIDINE DERIVATIVE INTERMEDIATES | SANOFI (FR) | 1998-04-21 | — | — | US | disclosed |
| EP-0673928-A1 | Novel N-(3,4-dichlorophenyl-propyl)-piperidine derivatives as selective human NK3-receptor antagonists | SANOFI (FR) | 1995-09-27 | — | — | EP | disclosed |