Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 1/20 | 0.52 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.47 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4630028 | 0.89 | CACNA1G (0.54) | CACNA1GOPRL1POLBNPFFR1NPFFR2 | |
| SCHEMBL4629996 | 0.85 | CACNA1G (0.55) | CACNA1GOPRL1POLBNPFFR1NPFFR2 | |
| SCHEMBL7304290 | 0.83 | NPFFR1 (0.53) | CACNA1GOPRL1POLBNPFFR1NPFFR2 | |
| SCHEMBL4631201 | 0.83 | BCHE (0.52) | CACNA1GOPRL1POLBNPFFR1NPFFR2 | |
| SCHEMBL7305853 | 0.79 | OPRM1 (0.45) | OPRL1CYP2D6OPRM1KCNA3CHRM2 | |
| SCHEMBL7304297 | 0.78 | NPFFR1 (0.59) | CACNA1GOPRL1POLBNPFFR1NPFFR2 | |
| SCHEMBL2808174 | 0.74 | OPRL1 (0.54) | CACNA1GOPRL1OPRM1SIGMAR1KDM4E | |
| SCHEMBL10254909 | 0.73 | OPRL1 (0.58) | OPRL1POLBNPFFR1NPFFR2CYP2D6 | |
| SCHEMBL2789160 | 0.72 | OPRL1 (0.66) | OPRL1POLBNPFFR1NPFFR2CYP2D6 | |
| SCHEMBL4630841 | 0.72 | NPFFR1 (0.51) | OPRL1POLBNPFFR1NPFFR2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294537-B1 | NEUROKININS USED FOR TREATMENT OF DISEASES | SANOFI-SYNTHELABO (FR) | 2001-09-25 | — | — | US | disclosed |
| US-5942523-A | NOVEL PIPERIDINE DERIVATIVES WHOSE SPECIFIC STRUCTURE INCLUDES AT POSITION 1 AN ALKYL CHAIN HAVING A 3,4-DICHLOROPHENYL GROUP ATTACHED; HIGH SELECTIVITY TO THE NK3 RECEPTOR; UNIT DOSAGE FORM; TREATING PSYCHIATRIC DISEASES | SANOFI (FR) | 1999-08-24 | — | — | US | disclosed |
| US-5741910-A | PIPERIDINE DERIVATIVE INTERMEDIATES | SANOFI (FR) | 1998-04-21 | — | — | US | disclosed |
| EP-0673928-A1 | Novel N-(3,4-dichlorophenyl-propyl)-piperidine derivatives as selective human NK3-receptor antagonists | SANOFI (FR) | 1995-09-27 | — | — | EP | disclosed |