Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 6/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7295525 | 0.96 | PDE3B (0.40) | PDE3BPDE3AGPR119ABCB11MAOA | |
| SCHEMBL7295544 | 0.81 | GPR119 (0.41) | PDE3BPDE3AGPR119 | |
| SCHEMBL7295661 | 0.81 | GPR119 (0.41) | PDE3BPDE3AGPR119 | |
| SCHEMBL7299013 | 0.80 | DYRK1A (0.37) | PDE3BPDE3AGPR119MAPTSMN1; SMN2 | |
| SCHEMBL7304449 | 0.80 | PDE3B (0.39) | PDE3BPDE3AGPR119MAPTSMN1; SMN2 | |
| SCHEMBL7329278 | 0.79 | GPR119 (0.45) | PDE3BPDE3AGPR119 | |
| SCHEMBL7328362 | 0.79 | HRH3 (0.47) | PDE3BPDE3AGPR119MAPTSMN1; SMN2 | |
| SCHEMBL10424705 | 0.77 | PDE3B (0.44) | PDE3BPDE3AGPR119ABCB11MAOA | |
| SCHEMBL9877075 | 0.77 | PDE3B (0.49) | PDE3BPDE3AGPR119ABCB11MAOA | |
| SCHEMBL9687447 | 0.76 | MAPK1 (0.41) | PDE3BPDE3AGPR119MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |