Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7295525 | 0.85 | PDE3B (0.40) | GPR119SMN1; SMN2PDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL7331760 | 0.83 | SMN1; SMN2 (0.40) | GPR119SMN1; SMN2KMT2APDE3BPDE3A | |
| SCHEMBL9687223 | 0.81 | PIK3CA (0.34) | GPR119EGFRERBB2HTTMEN1 | |
| SCHEMBL7304445 | 0.80 | PDE3B (0.39) | GPR119SMN1; SMN2PDE3BPDE3AMAPT | |
| SCHEMBL9687213 | 0.78 | MAPK1 (0.44) | SMN1; SMN2HTTMEN1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL9686815 | 0.76 | PDE3B (0.41) | SMN1; SMN2MEN1KMT2APDE3BKDM4E | |
| SCHEMBL7293305 | 0.72 | PDE3B (0.44) | GPR119SMN1; SMN2PDE4APDE4BPDE4C | |
| SCHEMBL9877849 | 0.70 | PDE3B (0.43) | GPR119SMN1; SMN2PDE4APDE4BPDE4C | |
| SCHEMBL7306568 | 0.69 | ADRB2 (0.39) | GPR119KMT2APDE4APDE4BPDE4C | |
| SCHEMBL7303647 | 0.69 | CTSS (0.45) | MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |