Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 9/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329278 | 0.92 | GPR119 (0.45) | HRH3PDE3BPDE3AGPR119PDE4A | |
| SCHEMBL7295525 | 0.80 | PDE3B (0.40) | PDE3BPDE3AGPR119SMN1; SMN2MAPT | |
| SCHEMBL7295661 | 0.79 | GPR119 (0.41) | PDE3BPDE3AGPR119 | |
| SCHEMBL7295544 | 0.78 | GPR119 (0.41) | PDE3BPDE3AGPR119 | |
| SCHEMBL9484349 | 0.71 | HRH3 (0.70) | HRH3PDE3BPDE3ASMN1; SMN2MAPT | |
| SCHEMBL7329284 | 0.70 | GPR119 (0.45) | GPR119SMN1; SMN2MAPTKCNH2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7331760 | 0.69 | SMN1; SMN2 (0.40) | PDE3BPDE3AGPR119SMN1; SMN2MAPT | |
| SCHEMBL7299789 | 0.68 | ADRB1 (0.49) | HRH3KDM4E | |
| SCHEMBL7305182 | 0.68 | HRH3 (0.46) | HRH3PDE3BPDE3AGPR119SMN1; SMN2 | |
| SCHEMBL7335953 | 0.67 | HRH3 (0.69) | HRH3PDE3BPDE3AGPR119SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |