Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | RORC | P51449 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HRH2 | P25021 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8696969 | 0.87 | RORC (0.58) | SMN1; SMN2NPC1RAB9ARORCCYP2C19 | |
| SCHEMBL8192046 | 0.82 | HTR1D (0.68) | — | |
| SCHEMBL29087277 | 0.80 | RORC (0.61) | SMN1; SMN2NPC1RAB9ARORCCYP2C19 | |
| SCHEMBL18110614 | 0.80 | RORC (0.54) | SMN1; SMN2NPC1RAB9ARORCCYP2C19 | |
| SCHEMBL7299616 | 0.79 | HTR1D (0.66) | — | |
| SCHEMBL31628389 | 0.78 | MEN1 (0.55) | SMN1; SMN2NPC1RAB9ACYP2C19TMEM97 | |
| SCHEMBL29976408 | 0.78 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1RAB9ACYP2C19TMEM97 | |
| SCHEMBL7305125 | 0.78 | CCR1 (0.45) | RORCHRH3MEN1KMT2A | |
| SCHEMBL13636153 | 0.78 | SIGMAR1 (0.65) | SMN1; SMN2NPC1RAB9ACYP2C19TMEM97 | |
| SCHEMBL7556949 | 0.78 | CHRM4 (0.61) | SMN1; SMN2NPC1RAB9ACYP2C19SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153611-A | AS NON-DOPAMINERGIC ANTIISCHEMIC COMPOUNDS FOR TREATING BRAIN DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-11-28 | — | — | US | disclosed |
| EP-0560669-B1 | Piperazinyl-and piperidinyl-cyclohexenes and cyclohexanes | BRISTOL MYERS SQUIBB CO (US) | 1995-06-14 | — | — | EP | disclosed |
| EP-0560669-A1 | Piperazinyl-and piperidinyl-cyclohexenes and cyclohexanes | Bristol-Myers Squibb Company (US) | 1993-09-15 | — | — | EP | disclosed |