Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NOS2 | P35228 | 1/20 | 0.52 |
| ▸ | CCR1 | P32246 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29087277 | 0.93 | RORC (0.61) | RORCMEN1KMT2ANPSR1CHRM4 | |
| SCHEMBL7556949 | 0.91 | CHRM4 (0.61) | MEN1KMT2ANPSR1CHRM4SMN1; SMN2 | |
| SCHEMBL19458995 | 0.88 | ACE2 (0.56) | RORCMEN1KMT2ANPSR1CHRM4 | |
| SCHEMBL15379133 | 0.88 | NOS2 (0.54) | RORCMEN1KMT2ANPSR1CHRM4 | |
| SCHEMBL16936275 | 0.88 | CCR1 (0.64) | MEN1KMT2ANPSR1CHRM4SMN1; SMN2 | |
| SCHEMBL18110614 | 0.87 | RORC (0.54) | RORCMEN1KMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL29087308 | 0.87 | MEN1 (0.53) | RORCMEN1KMT2ANPSR1CHRM4 | |
| SCHEMBL8693356 | 0.87 | RORC (0.54) | RORCMEN1KMT2ANPSR1CHRM4 | |
| SCHEMBL7304539 | 0.87 | SMN1; SMN2 (0.50) | RORCMEN1KMT2ANPSR1CHRM4 | |
| SCHEMBL751049 | 0.86 | OPRD1 (0.53) | MEN1KMT2ANPSR1CHRM4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5852040-A | Neuroprotective 3,4-dihydro-2(1H)-quinolone compounds | PFIZER INC. (US) | 1998-12-22 | — | — | US | disclosed |
| EP-0666854-B1 | NEUROPROTECTIVE 3,4-DIHYDRO-2(1H)-QUINOLONE COMPOUNDS | PFIZER (US) | 1997-03-26 | — | — | EP | disclosed |
| EP-0666854-A1 | NEUROPROTECTIVE 3,4-DIHYDRO-2(1H)-QUINOLONE COMPOUNDS. | PFIZER (US) | 1995-08-16 | — | — | EP | disclosed |
| WO-1994010166-A1 | NEUROPROTECTIVE 3,4-DIHYDRO-2(1H)-QUINOLONE COMPOUNDS | PFIZER INC. (US) | 1994-05-11 | — | — | WO | disclosed |