Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 10/20 | 0.81 |
| ▸ | PARL | Q9H300 | 1/20 | 0.63 |
| ▸ | TPSAB1 | Q15661 | 8/20 | 0.62 |
| ▸ | TPSD1 | Q9BZJ3 | 8/20 | 0.62 |
| ▸ | TPSG1 | Q9NRR2 | 8/20 | 0.62 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7289248 | 0.90 | ELANE (1.00) | ELANEPARLTPSAB1TPSD1TPSG1 | |
| SCHEMBL7306582 | 0.81 | ELANE (0.82) | ELANEPARLCA12CA9 | |
| SCHEMBL15276289 | 0.79 | ELANE (1.00) | ELANEPARLCA12CA2CA9 | |
| SCHEMBL7287088 | 0.75 | PARL (0.80) | ELANEPARLTPSAB1TPSD1TPSG1 | |
| SCHEMBL7383368 | 0.75 | ELANE (0.62) | ELANEPARLTPSAB1TPSD1TPSG1 | |
| SCHEMBL4029127 | 0.73 | CA12 (0.67) | ELANETPSAB1TPSD1TPSG1CA12 | |
| SCHEMBL9014634 | 0.73 | RAB9A (0.76) | ELANECA12CA2CA9 | |
| SCHEMBL7144141 | 0.72 | ELANE (0.67) | ELANEPARLTPSAB1TPSD1TPSG1 | |
| SCHEMBL7383061 | 0.70 | ELANE (0.72) | ELANEPARLCA12CA2CA9 | |
| SCHEMBL356403 | 0.70 | CA12 (0.69) | ELANECA12CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550111-B1 | 2-Saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and pharmaceutical compositions containing them | SANOFI SA (FR) | 1999-04-14 | — | — | EP | disclosed |
| US-5856349-A | 2-Saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof | SANOFI (FR) | 1999-01-05 | — | — | US | disclosed |
| US-5652254-A | TREATMENT OF DEGENERATIVE DISEASES, RHEUMATOID ARTHRITIS, PSORIASIS, CYSTIC FIBROSIS | SANOFI, S.A. (FR) | 1997-07-29 | — | — | US | disclosed |
| US-5563163-A | TREATMENT OF DEGENERATIVE DISEASES | STERLING WINTHROP, INC. (US) | 1996-10-08 | — | — | US | disclosed |
| US-5488062-A | 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof | STERLING WINTHROP INC. (US) | 1996-01-30 | — | — | US | disclosed |
| US-5376653-A | A protease enzyme inhibitor for treating degenerative diseases , respiratory system disorders, rheumatoid arthritis and pancreatitis | STERLING WINTHROP INC. (US) | 1994-12-27 | — | — | US | disclosed |
| EP-0550111-A1 | 2-Saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and pharmaceutical compositions containing them | STERLING WINTHROP INC. (US) | 1993-07-07 | — | — | EP | disclosed |