Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7306716 | 0.93 | ADORA2A (0.45) | KDM4ESMN1; SMN2NPC1RAB9APKM | |
| SCHEMBL7295510 | 0.80 | TAAR1 (0.46) | KDM4ESMN1; SMN2NPC1RAB9APKM | |
| SCHEMBL7165172 | 0.79 | NOS2 (0.49) | KDM4ESMN1; SMN2NPC1RAB9AADORA2A | |
| SCHEMBL7167684 | 0.75 | NOS2 (0.53) | KDM4ESMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL7299551 | 0.74 | KDM4E (0.46) | KDM4ESMN1; SMN2NPC1RAB9APKM | |
| Oxalic Acid SCHEMBL7298102 | 0.73 | RPS6KB1 (0.42) | KDM4ESMN1; SMN2NPC1RAB9AADORA2A | |
| SCHEMBL2309144 | 0.72 | MAPK1 (0.61) | SMN1; SMN2NPC1RAB9AMAPTKMT2A | |
| SCHEMBL20324683 | 0.71 | KDM4E (0.47) | KDM4EADORA2AADORA1ADORA2BKEAP1 | |
| SCHEMBL7303142 | 0.71 | ADORA2A (0.42) | KDM4ESMN1; SMN2NPC1RAB9APKM | |
| SCHEMBL7305553 | 0.71 | ADORA2A (0.44) | KDM4ESMN1; SMN2NPC1RAB9AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0604353-B1 | Benzimidazole compounds, their preparation and use | NEUROSEARCH AS (DK) | 1998-07-01 | — | — | EP | claimed |
| US-5441969-A | Imidazole compounds, their preparation and use | NEUROSEARCH A/S (DK) | 1995-08-15 | — | — | US | claimed |
| EP-0604353-A1 | Benzimidazole compounds, their preparation and use | NEUROSEARCH A/S (DK) | 1994-06-29 | — | — | EP | claimed |
| EP-0604353-B1 | Benzimidazole compounds, their preparation and use | NEUROSEARCH AS (DK) | 1998-07-01 | — | — | EP | disclosed |
| US-5441969-A | Imidazole compounds, their preparation and use | NEUROSEARCH A/S (DK) | 1995-08-15 | — | — | US | disclosed |
| EP-0604353-A1 | Benzimidazole compounds, their preparation and use | NEUROSEARCH A/S (DK) | 1994-06-29 | — | — | EP | disclosed |