Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27322968 | 0.90 | LMNA (0.47) | NAMPTLMNAMAPTMAPK1SLC18A3 | |
| SCHEMBL7300880 | 0.90 | LMNA (0.49) | NAMPTLMNAMAPTMAPK1SLC18A3 | |
| SCHEMBL8986417 | 0.84 | NAMPT (0.65) | NAMPTLMNAMAPTMAPK1RAB9A | |
| SCHEMBL1996214 | 0.80 | NAMPT (0.57) | NAMPTLMNAMAPTSMN1; SMN2RAB9A | |
| SCHEMBL1996211 | 0.80 | NAMPT (0.57) | NAMPTLMNAMAPTSMN1; SMN2RAB9A | |
| SCHEMBL8986471 | 0.79 | MAPT (0.58) | NAMPTLMNAMAPTHPGDKMT2A | |
| SCHEMBL7303971 | 0.78 | SLC18A3 (0.42) | NAMPTMAPTMAPK1SLC18A3RAB9A | |
| SCHEMBL187122 | 0.77 | P2RY14 (0.41) | NAMPTMAPTKMT2A | |
| SCHEMBL10813817 | 0.76 | LMNA (0.61) | LMNAHPGDCYP1A2SMN1; SMN2RAB9A | |
| SCHEMBL8986418 | 0.76 | LMNA (0.61) | LMNAHPGDCYP1A2SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657440-B1 | Oxazolidine-2-one derivatives as MAO inhibitors | HOFFMANN LA ROCHE (CH) | 2000-04-05 | — | — | EP | disclosed |
| EP-0657440-A1 | Oxazolidine-2-one derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-06-14 | — | — | EP | disclosed |