Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | QDPR | P09417 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27318172 | 0.87 | SLC18A3 (0.44) | SLC18A3NAMPTDDB1CRBNGPR119 | |
| SCHEMBL187122 | 0.85 | P2RY14 (0.41) | NAMPTGPR119MAPTP2RY14 | |
| SCHEMBL14764299 | 0.85 | DDB1 (0.41) | NAMPTDDB1CRBNGPR119MAPT | |
| SCHEMBL3724395 | 0.83 | GPR119 (0.46) | GPR119MAPTALDH1A1L3MBTL1KDM1A | |
| SCHEMBL7299890 | 0.82 | SLC18A3 (0.48) | SLC18A3NAMPTMAPTALDH1A1MAPK1 | |
| SCHEMBL270733 | 0.81 | NAMPT (0.60) | NAMPTDDB1CRBNGPR119NR1H2 | |
| SCHEMBL14764202 | 0.80 | TRPC6 (0.51) | — | |
| SCHEMBL27904323 | 0.80 | SLC18A3 (0.40) | SLC18A3NAMPTPDE4BQDPRMAPT | |
| SCHEMBL212216 | 0.79 | USP30 (0.46) | GPR119 | |
| SCHEMBL7305192 | 0.78 | NAMPT (0.47) | SLC18A3NAMPTMAPTNPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657440-B1 | Oxazolidine-2-one derivatives as MAO inhibitors | HOFFMANN LA ROCHE (CH) | 2000-04-05 | — | — | EP | disclosed |
| EP-0657440-A1 | Oxazolidine-2-one derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-06-14 | — | — | EP | disclosed |