Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Norfluoxetine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 5/20 | 0.87 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.87 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.87 |
| ▸ | KCNK2 | O95069 | 2/20 | 0.87 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.87 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.87 |
| ▸ | SLC7A5 | Q01650 | 4/20 | 0.72 |
| ▸ | SLC6A9 | P48067 | 6/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.61 |
| ▸ | MTOR | P42345 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | HTR2C | P28335 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Seproxetine SCHEMBL272873 | 0.93 | SLC6A4 (1.00) | SLC6A4SLC6A2SLC6A3KCNK2KCNH2 | |
| Norfluoxetine SCHEMBL686500 | 0.93 | SLC6A4 (1.00) | SLC6A4SLC6A2SLC6A3KCNK2KCNH2 | |
| Norfluoxetine SCHEMBL3750512 | 0.93 | SLC6A4 (1.00) | SLC6A4SLC6A2SLC6A3KCNK2KCNH2 | |
| Norfluoxetine SCHEMBL140929 | 0.92 | SLC6A4 (0.97) | SLC6A4SLC6A2SLC6A3KCNK2KCNH2 | |
| Seproxetine SCHEMBL120303 | 0.92 | SLC6A4 (0.97) | SLC6A4SLC6A2SLC6A3KCNK2KCNH2 | |
| Oxalic Acid SCHEMBL7409520 | 0.85 | SLC6A4 (0.62) | SLC6A4SLC6A2SLC6A3KCNK2KCNH2 | |
| SCHEMBL17267476 | 0.84 | SLC7A5 (1.00) | SLC6A4SLC6A2SLC6A3KCNK2KCNH2 | |
| SCHEMBL17267474 | 0.84 | SLC7A5 (1.00) | SLC6A4SLC6A2SLC6A3KCNK2KCNH2 | |
| SCHEMBL17267513 | 0.84 | SLC7A5 (1.00) | SLC6A4SLC6A2SLC6A3KCNK2KCNH2 | |
| Oxalic Acid SCHEMBL7317614 | 0.84 | SLC6A4 (0.88) | SLC6A4SLC6A2SLC6A3KCNK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4313896-A | ANTIDEPRESSANTS, PSYCHOTROPIC AGENTS | ELI LILLY AND COMPANY (US) | 1982-02-02 | — | — | US | claimed |
| US-4626549-A | Treatment of obesity with aryloxyphenylpropylamines | ELI LILLY AND COMPANY (US) | 1986-12-02 | — | — | US | disclosed |
| US-4313896-A | ANTIDEPRESSANTS, PSYCHOTROPIC AGENTS | ELI LILLY AND COMPANY (US) | 1982-02-02 | — | — | US | disclosed |
| US-4314081-A | ANTIDEPRESSANTS | ELI LILLY AND COMPANY (US) | 1982-02-02 | — | — | US | disclosed |
| US-4194009-A | ANTIDEPRESSANT | ELI LILLY AND COMPANY (US) | 1980-03-18 | — | — | US | disclosed |
| US-4018895-A | Aryloxyphenylpropylamines in treating depression | ELI LILLY AND COMPANY (US) | 1977-04-19 | — | — | US | disclosed |