Norfluoxetine — predicted protein targets

Known targets — ChEMBL curated mechanism

ABL1 ACE ACHE ACVR1 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 AGTR1 ALK AVPR1A AVPR2 BCHE BCR CA2 CACNA1A CACNA1B CACNA1C CACNA1D CACNA1E CACNA1F CACNA1G CACNA1H CACNA1I CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 CALCRL CASR CCR5 CDK4 CDK6 CFB CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CHRNA1 CHRNA3 CHRNA7 CHRNB1 CHRNB4 CHRND CHRNE CHRNG COXFA4 COXFA4L2 CRBN CSF1R CUL4A CYP19A1 DDB1 DPP4 DRD1 DRD2 DRD3 DRD4 EDNRA EGFR EML4 ERBB2 ERBB4 ESR1 ESR2 FGFR1 FGFR3 FLT1 FLT3 FLT4 GAA GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GABRE GABRG1 GABRG2 GABRG3 GABRP GABRQ GHSR GLA GNRHR GPD2 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B GSTP1 HCN4 HCRTR1 HCRTR2 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HRH1 HRH2 HRH3 HSD11B1 HSP90AA1 HSP90AB1 HTR1A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR3A HTR3B HTR3C HTR3D HTR3E HTR4 HTR5A HTR6 HTR7 IMPDH1 IMPDH2 ITGA2B ITGB3 ITK JAK1 JAK2 KCNA1 KCNA10 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNB1 KCNB2 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNF1 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNJ2 KCNJ3 KCNJ5 KCNK3 KCNK9 KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5 KCNS1 KCNS2 KCNS3 KCNV1 KCNV2 KDR KIT KLKB1 LCK M MAOA MAOB MAPK14 MET MMP1 MMP13 MMP7 MMP8 MT-ND1 MT-ND2 MT-ND3 MT-ND4 MT-ND4L MT-ND5 MT-ND6 NDUFA1 NDUFA10 NDUFA11 NDUFA12 NDUFA13 NDUFA2 NDUFA3 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA9 NDUFAB1 NDUFAF1 NDUFAF2 NDUFAF3 NDUFAF4 NDUFB1 NDUFB10 NDUFB11 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFS4 NDUFS5 NDUFS6 NDUFS7 NDUFS8 NDUFV1 NDUFV2 NDUFV3 NR3C1 NS5A NTRK1 NTRK2 NTRK3 ODC1 OPRD1 OPRK1 OPRM1 P2RY12 PAH PARP1 PDE3A PDE3B PDE4A PDE4B PDE4C PDE4D PDE5A PDE7A PDE7B PDE8A PDE8B PDGFRA PDGFRB PIK3CA PIK3CD PNP POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLE3 PPARG PRIM1 PRIM2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 PTGS1 PTGS2 RBX1 REN RET ROCK1 ROCK2 RPE65 RRM1 RRM2 RRM2B S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SCN10A SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A SCN9A SCNN1A SCNN1B SCNN1G SIGMAR1 SLC18A2 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC9A3 SRC TACR1 TOP1 TOP2A TOP2B TTR TYMP dacA dacB dacC embA folA ftsI gyrA gyrB mrcA mrcB mrdA parC parE pol rplA rplB rplC rplD rplE rplF rplI rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmE2 rpmF rpmG rpmG1 rpmG2 rpmG3 rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Norfluoxetine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	SLC6A4 known ✓	P31645	5/20	0.97

▸	SLC6A2 known ✓	P23975	4/20	0.97

▸	SLC6A3 known ✓	Q01959	4/20	0.97

▸	KCNH2 known ✓	Q12809	2/20	0.97

▸	CACNA1C known ✓	Q13936	2/20	0.97

▸	HTR2C known ✓	P28335	2/20	0.69

▸	HRH3 known ✓	Q9Y5N1	2/20	0.67

▸	CHRM2 known ✓	P08172	1/20	0.67

▸	CHRM5 known ✓	P08912	1/20	0.67

▸	ADRA2A known ✓	P08913	1/20	0.67

▸	CHRM1 known ✓	P11229	1/20	0.67

▸	DRD2 known ✓	P14416	1/20	0.67

▸	ADRA2B known ✓	P18089	1/20	0.67

▸	CHRM3 known ✓	P20309	1/20	0.67

▸	DRD1 known ✓	P21728	1/20	0.67

▸	ACHE known ✓	P22303	1/20	0.67

▸	HRH2 known ✓	P25021	1/20	0.67

▸	EDNRA known ✓	P25101	1/20	0.67

▸	HTR2A known ✓	P28223	1/20	0.67

▸	ADRA1A known ✓	P35348	1/20	0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Seproxetine SCHEMBL120303	1.00	SLC6A4 (0.97)	SLC6A4SLC6A2SLC6A3KCNK2KCNH2
Norfluoxetine SCHEMBL3750512	0.98	SLC6A4 (1.00)	SLC6A4SLC6A2SLC6A3KCNK2KCNH2
Norfluoxetine SCHEMBL686500	0.98	SLC6A4 (1.00)	SLC6A4SLC6A2SLC6A3KCNK2KCNH2
Seproxetine SCHEMBL272873	0.98	SLC6A4 (1.00)	SLC6A4SLC6A2SLC6A3KCNK2KCNH2
Norfluoxetine SCHEMBL7306073	0.92	SLC6A4 (0.87)	SLC6A4SLC6A2SLC6A3KCNK2KCNH2
SCHEMBL17267476	0.89	SLC7A5 (1.00)	SLC6A4SLC6A2SLC6A3KCNK2KCNH2
SCHEMBL17267513	0.89	SLC7A5 (1.00)	SLC6A4SLC6A2SLC6A3KCNK2KCNH2
SCHEMBL17267474	0.89	SLC7A5 (1.00)	SLC6A4SLC6A2SLC6A3KCNK2KCNH2
SCHEMBL17267515	0.87	SLC7A5 (1.00)	SLC6A4SLC6A2SLC6A3KCNK2KCNH2
SCHEMBL2738930	0.86	SLC6A4 (0.78)	SLC6A4SLC6A2SLC6A3KCNK2KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-4313896-A	ANTIDEPRESSANTS, PSYCHOTROPIC AGENTS	ELI LILLY AND COMPANY (US)	1982-02-02	—	—	US	claimed
US-4314081-A	ANTIDEPRESSANTS	ELI LILLY AND COMPANY (US)	1982-02-02	—	—	US	claimed
US-20120058979-A1	METHODS AND REAGENTS FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS	ZALICUS INC. (US)	2012-03-08	—	—	US	disclosed
US-8080553-B2	Methods and reagents for the treatment of immunoinflammatory disorders	ZALICUS INC. (US)	2011-12-20	—	—	US	disclosed
EP-2301628-A1	Methods and reagents for the treatment of immunoinflammatory disorders	Zalicus Inc. (US)	2011-03-30	—	—	EP	disclosed
EP-1735302-B1	4-AMINO-PIPERIDINE DERIVATIVES AS MONOAMINE UPTAKE INHIBITORS	LILLY CO ELI (US)	2010-06-16	—	—	EP	disclosed
US-20100092479-A1	Compositions and methods for treatment of viral diseases	COMBINATORX (SINGAPORE) PTE. LTD. (SG)	2010-04-15	—	—	US	disclosed
US-20100081713-A1	COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTIONS	CombinatoRx, (Singapore) Pte. Ltd.	2010-04-01	—	—	US	disclosed
WO-2010021681-A2	COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES	COMBINATORX (SINGAPORE) PTE. LTD. (SG)	2010-02-25	—	—	WO	disclosed
US-7619096-B2	3-Aminopyrrolidines as inhibitors of monoamine uptake	ELI LILLY AND COMPANY (US)	2009-11-17	—	—	US	disclosed
US-7615648-B2	Aminomethyl-azacycle derivatives as inhibitors of monoamine uptake	ELI LILLY AND COMPANY (US)	2009-11-10	—	—	US	disclosed
WO-2005000305-A1	3-AMINOPIPERIDINES AND 3-AMINOQUINUCLIDINES AS INHIBITORS OF MONOAMINE UPTAKE	ELI LILLY AND COMPANY (US)	2005-01-06	—	—	WO	disclosed
US-20040229849-A1	Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines	COMBINATORX, INCORPORATED	2004-11-18	—	—	US	disclosed
US-20040224876-A1	Combination therapy for the treatment of immunoinflammatory disorders	COMBINATORX, INCORPORATED	2004-11-11	—	—	US	disclosed
US-20040220153-A1	Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines	COMBINATORX, INCORPORATED	2004-11-04	—	—	US	disclosed
WO-2004073614-A2	COMBINATION THERAPY FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS	COMBINATORX, INCORPORATED (US)	2004-09-02	—	—	WO	disclosed
US-20040082666-A1	Inhibitor of monoamine uptake	MATTIUZ EDWARD LOUIS (US)	2004-04-29	—	—	US	disclosed
WO-2004030618-A2	METHODS AND REAGENTS FOR THE TREATMENT OF DISEASES AND DISORDERS ASSOCIATED WITH INCREASED LEVELS OF PROINFLAMMATORY CYTOKINES	COMBINATORX, INCORPORATED (US)	2004-04-15	—	—	WO	disclosed
EP-1379492-A1	INHIBITOR OF MONOAMINE UPTAKE	ELI LILLY AND COMPANY (US)	2004-01-14	—	—	EP	disclosed
WO-2002070457-A1	INHIBITOR OF MONOAMINE UPTAKE	ELI LILLY AND COMPANY (US)	2002-09-12	—	—	WO	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20100092479-A1	Compositions and methods for treatment of viral diseases	HAVCR2, RNASE1, EIF2AK2	SLC6A4 4825/4885SLC6A2 4758/4885SLC6A3 4742/4885
US-20040224876-A1	Combination therapy for the treatment of immunoinflammatory disorders	HLA-DRB1, TSLP, SERPINA6	SLC6A4 938/4885SLC6A2 1019/4885SLC6A3 1670/4885
US-20040220153-A1	Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines	TNF, IL5, IL6	SLC6A4 342/4885SLC6A2 562/4885SLC6A3 1714/4885
US-20040082666-A1	Inhibitor of monoamine uptake	SLC18A2, SLC6A2, SLC18A3	SLC6A4 4/4885SLC6A2 2/4885SLC6A3 5/4885
US-20040229849-A1	Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines	TNF, IL5, IL6	SLC6A4 342/4885SLC6A2 562/4885SLC6A3 1714/4885
US-20100081713-A1	COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTIONS	IFNG, IL5, HAVCR2	SLC6A4 4506/4885SLC6A2 4415/4885SLC6A3 4759/4885
US-20120058979-A1	METHODS AND REAGENTS FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS	IL5, TPMT, TSLP	SLC6A4 3269/4885SLC6A2 3188/4885SLC6A3 3683/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.