Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7291892 | 0.82 | NPC1 (0.55) | TSHRLMNAHPGDKMT2AMEN1 | |
| SCHEMBL29175212 | 0.81 | KMT2A (0.49) | LMNAKMT2AKDM4E | |
| SCHEMBL28899309 | 0.80 | NPC1 (0.58) | EPHX2TSHRLMNAHPGDGAA | |
| SCHEMBL1983309 | 0.80 | AKR1C3 (0.53) | EPHX2HPGDKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4470608 | 0.79 | GAA (0.49) | GAAMCOLN3NPSR1KDM4EALDH1A1 | |
| SCHEMBL4465339 | 0.79 | MLYCD (0.43) | TSHRLMNAHPGDGAAMCOLN3 | |
| SCHEMBL9149114 | 0.79 | TSHR (0.50) | TSHRLMNAHPGDKMT2AMEN1 | |
| SCHEMBL1536288 | 0.79 | HTT (0.55) | TSHRLMNAHPGDKMT2AMEN1 | |
| SCHEMBL3394380 | 0.79 | ALDH1A1 (0.59) | EPHX2TSHRLMNAHPGDGAA | |
| SCHEMBL22979384 | 0.77 | KDM4E (0.51) | EPHX2HPGDKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5597841-A | 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof | STERLING WINTHROP, INC. (US) | 1997-01-28 | — | — | US | disclosed |
| EP-0594257-B1 | 2-Saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof | STERLING WINTHROP INC (US) | 1996-07-10 | — | — | EP | disclosed |
| US-5512589-A | TREATING DEGENERATIVE DISEASES | STERLING WINTHROP INC. (US) | 1996-04-30 | — | — | US | disclosed |
| US-5306818-A | Treating degenerative diseases such as emphysema, rheumatoid arthritis and pancreatitis | STERLING WINTHROP INC. (US) | 1994-04-26 | — | — | US | disclosed |