Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLYCD | O95822 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.42 |
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.37 |
| ▸ | ESRRG | P62508 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29175212 | 0.83 | KMT2A (0.49) | MLYCDHSP90AA1HSP90AB1CES2LMNA | |
| SCHEMBL20178562 | 0.82 | ALDH1A1 (0.46) | CES2TSHRESRRGHPGD | |
| SCHEMBL4470608 | 0.82 | GAA (0.49) | MLYCDHSP90AA1HSP90AB1GAAMCOLN3 | |
| SCHEMBL23370109 | 0.81 | CES2 (0.43) | CES2ESRRG | |
| SCHEMBL14010461 | 0.80 | CES2 (0.42) | HSP90AB1CES2LMNAESRRGMAPK1 | |
| SCHEMBL23370103 | 0.80 | GPR52 (0.45) | CES2LMNAESRRGPDK2 | |
| SCHEMBL4469757 | 0.80 | HSP90AA1 (0.45) | MLYCDHSP90AA1HSP90AB1TSHRHPGD | |
| SCHEMBL7306129 | 0.79 | EPHX2 (0.46) | LMNAPDE4BTSHRGAAMCOLN3 | |
| SCHEMBL3558708 | 0.78 | HCRTR1 (0.47) | MLYCDHSP90AA1HSP90AB1PDE4BTSHR | |
| SCHEMBL10309762 | 0.78 | CFTR (0.49) | CES2TSHRGAAESRRGHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572805-B2 | Pyrrolo(oxo)isoquinolines as 5HT ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-11 | — | — | US | disclosed |
| US-20060014777-A1 | Pyrrolo(oxo)isoquinolines as 5HT ligands | BRISTOL-MYERS SQUIBB COMPANY | 2006-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014777-A1 | Pyrrolo(oxo)isoquinolines as 5HT ligands | HTR2B, OPRD1, HTR1B | MLYCD 1280/4885HSP90AA1 4652/4885HSP90AB1 4404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.