Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 5/20 | 0.49 |
| ▸ | PDE5A | O76074 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CTSC | P53634 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7308749 | 0.85 | LMNA (0.64) | TP53L3MBTL1ALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7304548 | 0.84 | LMNA (0.62) | TP53L3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL11325003 | 0.80 | MAPK1 (0.67) | TP53MAPK1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL7306211 | 0.80 | CTSS (0.52) | MME | |
| Bromide SCHEMBL11323260 | 0.79 | MAPK1 (0.66) | TP53MAPK1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL3817488 | 0.78 | L3MBTL1 (0.54) | MMETP53MAPK1L3MBTL1CTSC | |
| SCHEMBL27677789 | 0.78 | L3MBTL1 (0.54) | MMETP53MAPK1L3MBTL1CTSC | |
| SCHEMBL28767638 | 0.78 | L3MBTL1 (0.54) | MMETP53MAPK1L3MBTL1CTSC | |
| SCHEMBL7298742 | 0.77 | MME (0.46) | MMEPDE5ATP53MAPK1L3MBTL1 | |
| SCHEMBL3815434 | 0.77 | L3MBTL1 (0.44) | MMETP53MAPK1L3MBTL1CTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636630-B1 | N-heteroaryl substituted derivatives of propanamide useful in the treatment of cardiovascular diseases | ZAMBON SPA (IT) | 1999-04-28 | — | — | EP | disclosed |
| US-5438046-A | Enzyme inhibitors | ZAMBON GROUP S.P.A. (IT) | 1995-08-01 | — | — | US | disclosed |
| EP-0636630-A1 | N-heteroaryl substituted derivatives of propanamide useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.p.A. (IT) | 1995-02-01 | — | — | EP | disclosed |