Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7309339 | 0.87 | CYP2C19 (0.44) | MAPTKMT2AHSD11B1CYP2C19HIF1A | |
| SCHEMBL7313045 | 0.78 | HSD11B1 (0.39) | MAPTKMT2AHSD11B1ALDH1A1 | |
| SCHEMBL7479619 | 0.74 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL7478269 | 0.71 | MMP3 (0.57) | KMT2AALDH1A1NPC1RAB9ATSHR | |
| SCHEMBL7348556 | 0.70 | KMT2A (0.44) | MAPTKMT2AHSD11B1CYP2C19HIF1A | |
| SCHEMBL7306332 | 0.70 | CYP2C19 (0.41) | MAPTKMT2AHSD11B1CYP2C19ALDH1A1 | |
| SCHEMBL7302947 | 0.69 | MMP3 (0.59) | KMT2ANPC1RAB9ATSHRTDP1 | |
| SCHEMBL6245112 | 0.66 | ALDH1A1 (0.42) | MAPTKMT2AALDH1A1TSHR | |
| SCHEMBL2813766 | 0.65 | MAPT (0.55) | MAPTKMT2ACYP2C19HIF1AALDH1A1 | |
| SCHEMBL362442 | 0.65 | KMT2A (0.55) | MAPTKMT2ACYP2C19HIF1AESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931788-B1 | Metalloprotease inhibitors | PFIZER LTD (GB) | 2002-11-06 | — | — | EP | disclosed |
| US-6090852-A | MATRIX METALLOPROTEASE INHIBITOR | PFIZER INC (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0931788-A2 | Metalloprotease inhibitors | Pfizer Limited (GB) | 1999-07-28 | — | — | EP | disclosed |