Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9274595 | 0.99 | POLB (0.57) | POLBALDH1A1CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL7302514 | 0.90 | ITGB3 (0.54) | POLBALDH1A1CYP2C9CYP2C19TMPRSS6 | |
| SCHEMBL7295454 | 0.84 | ALDH1A1 (0.62) | POLBALDH1A1CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL9269854 | 0.84 | ALDH1A1 (0.58) | POLBALDH1A1CYP2C9CYP2C19SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9267868 | 0.84 | ALDH1A1 (0.61) | POLBALDH1A1CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL7301011 | 0.83 | POLB (0.57) | POLBALDH1A1CYP2C9CYP2C19SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9265744 | 0.82 | POLB (0.56) | POLBALDH1A1CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL7292847 | 0.81 | ITGB3 (0.56) | POLBSMN1; SMN2L3MBTL1NPC1GAA | |
| Hydrochloric Acid SCHEMBL9270486 | 0.80 | ITGB3 (0.55) | POLBL3MBTL1GAAF2ITGB3 | |
| SCHEMBL8407192 | 0.79 | PRSS1 (0.54) | POLBL3MBTL1GAAF2ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0381033-B1 | Carboxylic-acid and sulphonic-acid amides | HOFFMANN LA ROCHE (CH) | 1994-03-23 | — | — | EP | claimed |
| US-5256812-A | Antitumor agents, cardiovascular disorders; having amidino or guandino groups | HOFFMANN-LA ROCHE INC. (US) | 1993-10-26 | — | — | US | claimed |