Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 4/20 | 0.54 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.50 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.50 |
| ▸ | TMPRSS6 | Q8IU80 | 4/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.44 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7306473 | 0.90 | POLB (0.58) | ITGB3ITGA2BALDH1A1TMPRSS6F2 | |
| Hydrochloric Acid SCHEMBL9274595 | 0.89 | POLB (0.57) | ITGB3ITGA2BALDH1A1TMPRSS6F2 | |
| SCHEMBL7292860 | 0.85 | TBXA2R (0.72) | ITGB3ITGA2BALDH1A1TBXA2RTBXAS1 | |
| SCHEMBL7302709 | 0.83 | ITGB3 (0.49) | ITGB3ITGA2BALDH1A1TBXA2RTBXAS1 | |
| SCHEMBL9452076 | 0.82 | MEP1B (0.58) | ITGB3ITGA2BTBXA2RTMPRSS6KAT6A | |
| SCHEMBL7122825 | 0.81 | ITGB3 (0.75) | ITGB3ITGA2BF2PRSS1 | |
| SCHEMBL7291480 | 0.80 | ITGB3 (0.66) | ITGB3ITGA2BF2PRSS1 | |
| Hydrochloric Acid SCHEMBL8040370 | 0.80 | ITGB3 (0.73) | ITGB3ITGA2BF2PRSS1 | |
| SCHEMBL7294121 | 0.80 | ITGB3 (0.67) | ITGB3ITGA2BALDH1A1F2PRSS1 | |
| SCHEMBL7670445 | 0.79 | TMPRSS6 (0.51) | ITGB3ITGA2BTMPRSS6F2MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0381033-B1 | Carboxylic-acid and sulphonic-acid amides | HOFFMANN LA ROCHE (CH) | 1994-03-23 | — | — | EP | claimed |
| EP-0381033-A1 | Carboxylic-acid and sulphonic-acid amides | F. HOFFMANN-LA ROCHE AG (CH) | 1990-08-08 | — | — | EP | claimed |
| US-5399585-A | Anitcoagulants, antiinflammatory, antitumor | HOFFMANN-LA ROCHE INC. (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0381033-B1 | Carboxylic-acid and sulphonic-acid amides | HOFFMANN LA ROCHE (CH) | 1994-03-23 | — | — | EP | disclosed |
| US-5256812-A | Antitumor agents, cardiovascular disorders; having amidino or guandino groups | HOFFMANN-LA ROCHE INC. (US) | 1993-10-26 | — | — | US | disclosed |
| US-5084466-A | Anticoagulants, antiinflammatory agents, atheriosclerosis and antitumor agents | HOFFMANN-LA ROCHE INC. (US) | 1992-01-28 | — | — | US | disclosed |
| EP-0381033-A1 | Carboxylic-acid and sulphonic-acid amides | F. HOFFMANN-LA ROCHE AG (CH) | 1990-08-08 | — | — | EP | disclosed |