Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | STS | P08842 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7235475 | 0.85 | USP30 (0.32) | TP53GPR119USP30 | |
| SCHEMBL7311913 | 0.84 | TP53 (0.47) | TP53GPR119USP30JAK2JAK1 | |
| SCHEMBL7313802 | 0.81 | HTR2B (0.36) | — | |
| SCHEMBL7236582 | 0.79 | CHRM2 (0.38) | GPR119RECQLMAPT | |
| SCHEMBL7227965 | 0.78 | HTR2B (0.37) | — | |
| SCHEMBL25614813 | 0.78 | VNN1 (0.47) | TP53GPR119USP30FPR2RECQL | |
| SCHEMBL12356915 | 0.78 | HTR2B (0.40) | — | |
| SCHEMBL12356916 | 0.78 | HTR2B (0.40) | — | |
| SCHEMBL7228352 | 0.78 | CHRM2 (0.41) | GPR119EPHX2 | |
| SCHEMBL7227670 | 0.78 | CHRM2 (0.41) | GPR119EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5776937-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-07-07 | — | — | US | disclosed |
| EP-0711770-A1 | Antagonists of adhesion receptors | MERCK PATENT GmbH (DE) | 1996-05-15 | — | — | EP | disclosed |