Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7227670 | 0.98 | CHRM2 (0.41) | CHRM2CHRM1GPR119STAT3EPHX2 | |
| SCHEMBL7236582 | 0.94 | CHRM2 (0.38) | CHRM2CHRM1GPR119STAT3ACKR3 | |
| SCHEMBL7313917 | 0.86 | SIGMAR1 (0.34) | CHRM2CHRM1STAT3MAPK1L3MBTL1 | |
| SCHEMBL7310460 | 0.85 | SIGMAR1 (0.34) | CHRM2CHRM1STAT3MAPK1L3MBTL1 | |
| SCHEMBL7306386 | 0.82 | MAPK1 (0.47) | MAPK1L3MBTL1 | |
| SCHEMBL7313718 | 0.81 | SIGMAR1 (0.31) | MAPK1L3MBTL1 | |
| SCHEMBL7316915 | 0.80 | MAPK1 (0.45) | MAPK1L3MBTL1 | |
| SCHEMBL7306591 | 0.78 | TP53 (0.42) | GPR119EPHX2 | |
| SCHEMBL7310863 | 0.77 | MAPK1 (0.40) | MAPK1L3MBTL1 | |
| SCHEMBL7314450 | 0.77 | HTR7 (0.41) | CHRM2CHRM1MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602876-B1 | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2003-08-05 | — | — | US | disclosed |
| US-6204280-B1 | OXAZOLIDINONE DERIVATIVE, ANTICOAGULANT | MERCK PATENT GESELLSCHAFT MIT BERSCHRANKTER HAFTUNG (DE) | 2001-03-20 | — | — | US | disclosed |
| EP-0710657-B1 | Antagonists of adhesion receptors | MERCK PATENT GMBH (DE) | 1998-08-26 | — | — | EP | disclosed |
| EP-0710657-A1 | Antagonists of adhesion receptors | MERCK PATENT GmbH (DE) | 1996-05-08 | — | — | EP | disclosed |