Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9686827 | 0.96 | MAPT (0.43) | MAPTKMT2ALMNANPY1RNPY2R | |
| SCHEMBL7296611 | 0.88 | MAPT (0.39) | MAPTKMT2ALMNANPY1RNPY2R | |
| SCHEMBL7294522 | 0.88 | MAPT (0.40) | MAPTKMT2ALMNANPY1RNPY2R | |
| SCHEMBL7293811 | 0.86 | ADRB1 (0.44) | MAPTKMT2ALMNANPY1RNPY2R | |
| SCHEMBL7305917 | 0.86 | MAPT (0.42) | MAPTKMT2ALMNANPY1RNPY2R | |
| SCHEMBL7296670 | 0.85 | LMNA (0.43) | MAPTKMT2ALMNANPY1RNPY2R | |
| SCHEMBL7298235 | 0.85 | MAPT (0.42) | MAPTKMT2ALMNANPY1RNPY2R | |
| SCHEMBL7303317 | 0.85 | MAPT (0.42) | MAPTKMT2ALMNANPY1RNPY2R | |
| Hydrochloric Acid SCHEMBL7362586 | 0.84 | ADRB2 (0.44) | MAPTKMT2ALMNANPY1RNPY2R | |
| SCHEMBL7301195 | 0.83 | HRH3 (0.40) | KMT2ALMNAHRH3ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | claimed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | claimed |
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |