Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9686827 | 0.87 | MAPT (0.43) | HRH3ADRB1LMNACYP2D6MEN1 | |
| SCHEMBL7303813 | 0.83 | ABCB11 (0.39) | HRH3GPR119PDE3BPDE3A | |
| SCHEMBL7306723 | 0.83 | MAPT (0.40) | HRH3ADRB1LMNACYP2D6MEN1 | |
| SCHEMBL7303819 | 0.82 | PDE3B (0.46) | HRH3GPR119PDE3BPDE3A | |
| SCHEMBL7298686 | 0.81 | ADRB3 (0.37) | ADRB1LMNACYP2D6MEN1CYP1A2 | |
| SCHEMBL7293811 | 0.79 | ADRB1 (0.44) | HRH3ADRB1LMNACYP2D6MEN1 | |
| SCHEMBL7296670 | 0.78 | LMNA (0.43) | HRH3ADRB1LMNACYP2D6MEN1 | |
| SCHEMBL7298235 | 0.77 | MAPT (0.42) | HRH3ADRB1LMNACYP2D6MEN1 | |
| SCHEMBL7294522 | 0.77 | MAPT (0.40) | HRH3ADRB1LMNACYP2D6MEN1 | |
| SCHEMBL7305917 | 0.76 | MAPT (0.42) | HRH3ADRB1LMNACYP2D6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |