Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7299565 | 0.88 | NR1H2 (0.44) | MEN1KMT2ANR1H2DRD2ALDH1A1 | |
| SCHEMBL12277410 | 0.83 | NR1H2 (0.43) | MEN1KMT2ANR1H2DRD2ALDH1A1 | |
| SCHEMBL24192400 | 0.83 | ACACB (0.51) | ACACBPRMT5WDR77MEN1KMT2A | |
| SCHEMBL30782330 | 0.82 | DRD2 (0.48) | ACACBMEN1KMT2ADRD2HSD17B10 | |
| SCHEMBL29341704 | 0.81 | DRD2 (0.42) | MEN1KMT2ANR1H2DRD2ALDH1A1 | |
| SCHEMBL2014179 | 0.80 | DRD2 (0.56) | PRMT5WDR77MEN1KMT2ADRD2 | |
| SCHEMBL7307274 | 0.80 | ITGB3 (0.60) | MEN1KMT2ADRD2LMNA | |
| SCHEMBL29589913 | 0.80 | NR1H2 (0.67) | NR1H2KDM4EMAPTMAPK1HDAC6 | |
| SCHEMBL2277894 | 0.80 | NR1H2 (0.67) | NR1H2KDM4EMAPTMAPK1HDAC6 | |
| SCHEMBL7300982 | 0.79 | KDM4E (0.55) | MEN1KMT2ADRD2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709370-B1 | Bicyclic compounds useful as platelet aggregation inhibitors | MITSUI CHEMICALS INC (JP) | 1999-01-13 | — | — | EP | disclosed |
| US-5629321-A | FIBRINOGEN ANTAGONIST | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-13 | — | — | US | disclosed |
| EP-0709370-A1 | Bicyclic compounds useful as platelet aggregation inhibitors | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-05-01 | — | — | EP | disclosed |