Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.83 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | AR | P10275 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.56 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | PREP | P48147 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1221986 | 0.91 | POLB (1.00) | POLBL3MBTL1NPC1RAB9ATDP1 | |
| SCHEMBL17551531 | 0.83 | SIGMAR1 (0.59) | POLBNPC1RAB9AARTDP1 | |
| SCHEMBL8599293 | 0.83 | NPC1 (0.81) | NPC1RAB9AARTDP1SMN1; SMN2 | |
| SCHEMBL17117487 | 0.82 | POLB (0.61) | POLBNPC1RAB9AARTDP1 | |
| SCHEMBL7309037 | 0.81 | L3MBTL1 (1.00) | POLBL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7730871 | 0.81 | NPC1 (0.68) | POLBL3MBTL1NPC1RAB9AAR | |
| SCHEMBL10371234 | 0.81 | NPC1 (0.78) | NPC1RAB9AARTDP1SMN1; SMN2 | |
| SCHEMBL24533902 | 0.81 | POLB (0.56) | POLBNPC1RAB9AARTDP1 | |
| SCHEMBL26107974 | 0.81 | POLB (0.59) | POLBNPC1RAB9ATDP1CACNA1G | |
| SCHEMBL26113012 | 0.81 | POLB (0.59) | POLBNPC1RAB9ATDP1CACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520336-A2 | Aldehyde derivatives and their use as calpain inhibitors | FUJIREBIO Inc. (JP) | 1992-12-30 | — | — | EP | disclosed |