Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 9/20 | 0.53 |
| ▸ | CTSL | P07711 | 8/20 | 0.53 |
| ▸ | CTSB | P07858 | 6/20 | 0.53 |
| ▸ | CTSK | P43235 | 7/20 | 0.51 |
| ▸ | TACR1 | P25103 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7308646 | 0.88 | CTSS (0.53) | CTSSCTSLCTSBCTSKTACR1 | |
| SCHEMBL478316 | 0.87 | SYK (0.54) | CTSSCTSLCTSBCTSKSYK | |
| SCHEMBL738204 | 0.87 | SYK (0.54) | CTSSCTSLCTSBCTSKSYK | |
| SCHEMBL9800760 | 0.86 | SYK (0.53) | CTSSCTSLCTSBCTSKSYK | |
| SCHEMBL10257423 | 0.85 | CTSD (0.53) | CTSSCTSLCTSBCTSKSYK | |
| SCHEMBL12195056 | 0.85 | CTSD (0.53) | CTSSCTSLCTSBCTSKSYK | |
| SCHEMBL12493693 | 0.84 | CTRB1 (0.55) | CTSSCTSLCTSBCTSKSYK | |
| SCHEMBL7333862 | 0.84 | CTRB1 (0.55) | CTSSCTSLCTSBCTSKSYK | |
| SCHEMBL15889351 | 0.84 | SYK (0.52) | CTSSCTSLCTSBCTSKSYK | |
| SCHEMBL25272324 | 0.83 | SYK (0.54) | CTSSCTSLCTSBCTSKSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0575844-B1 | Hydroxamic acid derivatives and pharmaceutical compositions thereof | HOFFMANN LA ROCHE (CH) | 1998-01-21 | — | — | EP | disclosed |
| EP-0575844-A2 | Hydroxamic acid derivatives and pharmaceutical compositions thereof | F. HOFFMANN-LA ROCHE AG (CH) | 1993-12-29 | — | — | EP | disclosed |