Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 8/20 | 0.53 |
| ▸ | CTSL | P07711 | 7/20 | 0.53 |
| ▸ | CTSB | P07858 | 5/20 | 0.53 |
| ▸ | TACR1 | P25103 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 5/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8649599 | 0.91 | MMP2 (0.54) | CTSSCTSLCTSBCTSKSYK | |
| SCHEMBL8280590 | 0.91 | MMP2 (0.54) | CTSSCTSLCTSBCTSKSYK | |
| SCHEMBL7307186 | 0.88 | CTSS (0.53) | CTSSCTSLCTSBTACR1CTSK | |
| SCHEMBL29231568 | 0.84 | CTSL (0.54) | CTSSCTSLCTSBCTSKCYP3A4 | |
| SCHEMBL7761992 | 0.81 | SYK (0.53) | CTSSCTSLCTSBCTSKSYK | |
| SCHEMBL12195056 | 0.79 | CTSD (0.53) | CTSSCTSLCTSBCTSKSYK | |
| SCHEMBL10257423 | 0.79 | CTSD (0.53) | CTSSCTSLCTSBCTSKSYK | |
| SCHEMBL6182844 | 0.79 | CTSS (0.71) | CTSSCTSLCTSBTACR1CTSK | |
| SCHEMBL23604935 | 0.78 | CTSK (0.63) | CTSSCTSLCTSBCTSKCYP3A4 | |
| SCHEMBL478316 | 0.78 | SYK (0.54) | CTSSCTSLCTSBCTSKSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0575844-B1 | Hydroxamic acid derivatives and pharmaceutical compositions thereof | HOFFMANN LA ROCHE (CH) | 1998-01-21 | — | — | EP | disclosed |
| EP-0575844-A2 | Hydroxamic acid derivatives and pharmaceutical compositions thereof | F. HOFFMANN-LA ROCHE AG (CH) | 1993-12-29 | — | — | EP | disclosed |