Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 2/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7307448 | 0.75 | PGR (0.35) | MAPTSMN1; SMN2CA12CA1CA2 | |
| SCHEMBL7306055 | 0.73 | HDAC3 (0.37) | CYP2D6CYP2E1CYP3A4CYP2A6CYP2C9 | |
| SCHEMBL6286439 | 0.72 | TP53 (0.36) | MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL7312968 | 0.72 | EPHX1 (0.32) | CYP2D6CYP2E1CYP3A4CYP2A6CYP2C9 | |
| SCHEMBL7297199 | 0.71 | MME (0.35) | CYP2D6CYP2E1CYP3A4CYP2A6CYP2C9 | |
| SCHEMBL7300483 | 0.71 | MAPK8 (0.33) | CYP3A4MAPTSMN1; SMN2CA12CA1 | |
| SCHEMBL8591055 | 0.69 | MAPT (0.44) | MAPTSMN1; SMN2CYP1A2MAPK1APOBEC3A | |
| SCHEMBL7302686 | 0.69 | KMT2A (0.36) | MAPTCA9L3MBTL1LMNAHPGD | |
| SCHEMBL7311782 | 0.69 | ALDH1A1 (0.36) | MAPK1 | |
| SCHEMBL28033340 | 0.69 | TAAR1 (0.45) | CYP2D6CYP2E1CYP3A4CYP2A6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0634396-B1 | Amino acid derivatives and their use as inhibitors of encephalinase | BIOPROJET SOC CIV (FR) | 1998-10-28 | — | — | EP | disclosed |
| EP-0634396-A1 | Amino acid derivatives and their use as inhibitors of encephalinase | SOCIETE CIVILE BIOPROJET (FR) | 1995-01-18 | — | — | EP | disclosed |