SCHEMBL28033340

SCHEMBL28033340

NCc1[c]c(-c2ccccc2)ccc1

nearest known ligand 0.45

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 2/20 0.45
LOXL2 Q9Y4K0 2/20 0.41
CYP3A4 P08684 3/20 0.38
CYP2E1 P05181 2/20 0.38
CYP2A6 P11509 2/20 0.38
CYP2C9 P11712 2/20 0.38
CYP2B6 P20813 2/20 0.38
CYP2C19 P33261 2/20 0.38
DPP4 P27487 2/20 0.38
CYP2D6 P10635 1/20 0.34
NOTUM Q6P988 2/20 0.32
CHRNB2 P17787 1/20 0.32
CHRNA4 P43681 1/20 0.32
ALDH1A1 P00352 1/20 0.32
CSNK2A1 P68400 2/20 0.32
MAOA P21397 1/20 0.31
HRH3 Q9Y5N1 1/20 0.31
HSD17B10 Q99714 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27634924 0.82 TAAR1 (0.38) TAAR1DPP4NOTUMHRH3
SCHEMBL27961621 0.82 LOXL2 (0.43) TAAR1LOXL2DPP4HRH3
SCHEMBL7311782 0.79 ALDH1A1 (0.36) TAAR1ALDH1A1
SCHEMBL6286439 0.79 TP53 (0.36) TAAR1ALDH1A1
SCHEMBL17697662 0.78 CALM1 (0.42) TAAR1LOXL2CYP3A4CYP2C9CYP2C19
SCHEMBL379055 0.77 ALDH1A1 (0.47) TAAR1CYP3A4NOTUMALDH1A1MAOA
SCHEMBL28087459 0.77 LOXL2 (0.43) TAAR1LOXL2CYP3A4CYP2E1CYP2A6
SCHEMBL4757375 0.75 KDM4E (0.45) TAAR1CYP3A4
SCHEMBL15756039 0.75 GABRA1 (0.35)
SCHEMBL27472235 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104926628-A Method for synthesizing benzil derivative UNIV ZHEJIANG TECHNOLOGY 2015-09-23 CN disclosed