Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 16/20 | 0.54 |
| ▸ | MMP13 | P45452 | 13/20 | 0.54 |
| ▸ | MMP1 | P03956 | 10/20 | 0.54 |
| ▸ | MMP3 | P08254 | 3/20 | 0.49 |
| ▸ | MMP9 | P14780 | 3/20 | 0.49 |
| ▸ | MMP8 | P22894 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7308291 | 0.73 | MAPK13 (0.42) | MMP2MMP13MMP1MMP8HPGD | |
| SCHEMBL7299694 | 0.73 | MMP13 (0.62) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL6764639 | 0.73 | PRMT1 (0.55) | MMP2MMP13MMP1MMP9LMNA | |
| SCHEMBL27478781 | 0.72 | MMP13 (0.55) | MMP2MMP13MMP1MMP9 | |
| SCHEMBL3693488 | 0.72 | HSD11B1 (0.58) | MMP2MMP13MMP1HPGDELANE | |
| SCHEMBL27497483 | 0.71 | CA12 (0.54) | MMP2MMP1MMP3MMP9MMP8 | |
| SCHEMBL6129828 | 0.71 | HSD11B1 (0.56) | MMP2MMP13MMP1HPGDELANE | |
| SCHEMBL7809330 | 0.71 | MMP2 (0.68) | MMP2MMP1MMP3MMP9MMP8 | |
| SCHEMBL6767563 | 0.70 | MMP13 (0.77) | MMP2MMP13MMP1 | |
| SCHEMBL6767568 | 0.70 | MMP13 (0.77) | MMP2MMP13MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |