Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.51 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.45 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.45 |
| ▸ | HTR2B known ✓ | P41595 | 2/20 | 0.45 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.45 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.45 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9451729 | 1.00 | MEN1 (0.51) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| Fumaric Acid SCHEMBL7300329 | 0.90 | MAPT (0.53) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| Fumaric Acid SCHEMBL9451626 | 0.90 | MAPT (0.53) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9451699 | 0.87 | SIRT6 (0.51) | MEN1KMT2AMAPTALDH1A1POLB | |
| Fumaric Acid SCHEMBL9451679 | 0.86 | SIGMAR1 (0.52) | MAPTALDH1A1CYP2C19CYP2C9MCHR1 | |
| Fumaric Acid SCHEMBL9451677 | 0.86 | SIGMAR1 (0.52) | MAPTALDH1A1CYP2C19CYP2C9MCHR1 | |
| Fumaric Acid SCHEMBL9451757 | 0.85 | HTR2A (0.51) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| Fumaric Acid SCHEMBL9451762 | 0.85 | HTR2A (0.51) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| Fumaric Acid SCHEMBL9451701 | 0.84 | HTR2A (0.50) | MCHR1HTR2AHTR2CHTR2BSIGMAR1 | |
| Fumaric Acid SCHEMBL9451571 | 0.84 | MCHR1 (0.55) | KMT2AMCHR1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0481299-B1 | N-phenyl-piperidyl-4-amines and drugs containing them | BASF AG (DE) | 1994-07-20 | — | — | EP | disclosed |
| US-5260318-A | Phenylpiperidylamines and drugs containing them | BASF AKTIENGESELLSCHAFT (DE) | 1993-11-09 | — | — | US | disclosed |
| EP-0481299-A2 | N-phenyl-piperidyl-4-amines and drugs containing them | BASF Aktiengesellschaft (DE) | 1992-04-22 | — | — | EP | disclosed |