Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | ALDH1A3 | P47895 | 3/20 | 0.42 |
| ▸ | ALDH1A2 | O94788 | 2/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4672079 | 0.89 | ALDH1A3 (0.54) | JAK2DYRK1AALDH1A3ALDH1A2NUDT1 | |
| SCHEMBL2900371 | 0.84 | CCNE2 (0.47) | JAK2DYRK1AALDH1A3ALDH1A2NUDT1 | |
| SCHEMBL1431759 | 0.84 | TNKS (0.47) | JAK2ALDH1A3ALDH1A2NUDT1KDR | |
| SCHEMBL7311707 | 0.84 | KDR (0.48) | JAK2DYRK1AADORA2AALDH1A3ALDH1A2 | |
| SCHEMBL7317792 | 0.84 | ALDH1A3 (0.54) | JAK2ALDH1A3ALDH1A2NUDT1KDR | |
| SCHEMBL12970128 | 0.81 | MKNK1 (0.40) | JAK2ALDH1A3ALDH1A2NUDT1HDAC8 | |
| SCHEMBL7311978 | 0.80 | MEN1 (0.54) | LMNAMAPTNOTUM | |
| SCHEMBL13574557 | 0.79 | FYN (0.38) | ALDH1A3ALDH1A2NUDT1ADRA1DADRA1A | |
| SCHEMBL7318740 | 0.79 | ALDH1A1 (0.44) | JAK2ALDH1A3ALDH1A2 | |
| SCHEMBL3315531 | 0.78 | NUDT1 (0.42) | ALDH1A3ALDH1A2NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240182467-A1 | INHIBITORS OF RAF KINASES | Pierre Fabre Médicament (FR) | 2024-06-06 | — | — | US | disclosed |
| US-11814384-B2 | Inhibtors of Raf kinases | KINNATE BIOPHARMA INC. (US) | 2023-11-14 | — | — | US | disclosed |
| US-4596872-A | Imidazo[1,2-a]pyridines, and process for their preparation | SCHERING A.G. (DE) | 1986-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240182467-A1 | INHIBITORS OF RAF KINASES | BRAF, RAF1, ARAF | JAK2 54/4885DYRK1A 534/4885ADORA2A 3874/4885 |
| US-11814384-B2 | Inhibtors of Raf kinases | RAF1, BRAF, ARAF | JAK2 229/4885DYRK1A 763/4885ADORA2A 3620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.