Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 10/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 8/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312955 | 0.89 | ADRB2 (0.57) | KDM4EALDH1A1KMT2AADRB2ADRB1 | |
| SCHEMBL7319579 | 0.85 | MEN1 (0.61) | ALDH1A1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL7302638 | 0.84 | ALDH1A1 (0.60) | KDM4EALDH1A1KMT2AADRB2ADRB1 | |
| SCHEMBL7315445 | 0.83 | ADRB3 (0.56) | KDM4EALDH1A1KMT2AADRB2ADRB1 | |
| SCHEMBL7319524 | 0.83 | CASR (0.60) | ADRB2ADRB1ADRB3 | |
| SCHEMBL7317641 | 0.82 | ADRB2 (0.67) | KDM4EADRB2ADRB1ADRB3HTR1A | |
| SCHEMBL7314435 | 0.82 | ADRB3 (0.55) | KDM4EALDH1A1KMT2AADRB2ADRB1 | |
| SCHEMBL7311030 | 0.82 | ADRB3 (0.55) | KDM4EALDH1A1KMT2AADRB2ADRB1 | |
| SCHEMBL7311964 | 0.81 | MAPT (0.57) | KMT2AADRB2ADRB1ADRB3HTR1A | |
| SCHEMBL7307680 | 0.81 | ADRB2 (0.55) | KDM4EALDH1A1KMT2AADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4258062-A | ISOPRENALINE ANTAGONISTS EFFECTING HEART RATE AND BLOOD PRESSURE | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-03-24 | — | — | US | disclosed |
| US-4171370-A | Phenoxy-amino-propanols | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1979-10-16 | — | — | US | disclosed |