Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.36 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 8/20 | 0.34 |
| ▸ | PPARA | Q07869 | 6/20 | 0.34 |
| ▸ | CTSS | P25774 | 2/20 | 0.34 |
| ▸ | CTSK | P43235 | 2/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7301211 | 0.84 | MME (0.41) | MMEMMP2 | |
| SCHEMBL7301071 | 0.83 | CTSS (0.41) | ACELMNAPPARGPPARACTSS | |
| SCHEMBL7302926 | 0.81 | CPA1 (0.44) | MMP12ALDH1A1PPARGPPARAMMP2 | |
| SCHEMBL7311029 | 0.80 | CTSS (0.39) | ACEKLK5MEN1ALDH1A1LMNA | |
| SCHEMBL7309312 | 0.78 | SLC6A4 (0.41) | ACEKLK5LMNACTSSCTSK | |
| SCHEMBL7308114 | 0.77 | MMP2 (0.44) | ACEKLK5MEN1ALDH1A1LMNA | |
| SCHEMBL7310171 | 0.77 | SIRT5 (0.44) | MEN1ALDH1A1LMNAKMT2APPARG | |
| SCHEMBL27478790 | 0.76 | PPARG (0.48) | PPARGPPARA | |
| SCHEMBL7310105 | 0.75 | PPARG (0.42) | PPARGPPARAMMP2MMP13 | |
| SCHEMBL7304806 | 0.75 | PPARG (0.44) | ALDH1A1KMT2APPARGPPARAMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |