Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 2/20 | 0.40 |
| ▸ | FCER2 | P06734 | 2/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 2/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | ECE1 | P42892 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302926 | 0.88 | CPA1 (0.44) | FOLH1MMP2MMP9 | |
| SCHEMBL7309324 | 0.84 | ACE (0.36) | MMEMMP2 | |
| SCHEMBL7301831 | 0.80 | MMP9 (0.47) | MMEMMP1FCER2LTA4HANPEP | |
| SCHEMBL7300405 | 0.76 | MME (0.50) | MMEMMP1FCER2LTA4HANPEP | |
| SCHEMBL7301205 | 0.75 | MME (0.46) | MMEMMP1FCER2LTA4HANPEP | |
| SCHEMBL7306329 | 0.73 | MMP1 (0.53) | MMEMMP1FCER2MMP2MMP9 | |
| SCHEMBL7298887 | 0.73 | ANPEP (0.52) | MMEFCER2FOLH1LTA4HANPEP | |
| SCHEMBL7299665 | 0.72 | MME (0.42) | MMEMMP1FCER2LTA4HANPEP | |
| SCHEMBL27479584 | 0.72 | PPARG (0.49) | MMEFOLH1LTA4HANPEPECE1 | |
| SCHEMBL6819843 | 0.70 | PDE4A (0.53) | MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |