Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 10/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 10/20 | 0.48 |
| ▸ | F2 | P00734 | 3/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.47 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.47 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.47 |
| ▸ | KLK1 | P06870 | 1/20 | 0.45 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7299794 | 0.89 | ITGB3 (0.56) | NPC1RAB9AALDH1A1TP53MAPT | |
| SCHEMBL7308736 | 0.83 | MAOB (0.51) | NPC1RAB9AALDH1A1TP53MAPT | |
| SCHEMBL7301801 | 0.81 | PLAU (0.48) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7305870 | 0.80 | NPC1 (0.41) | NPC1RAB9AALDH1A1TP53MAPT | |
| SCHEMBL7305877 | 0.80 | NPC1 (0.41) | NPC1RAB9AALDH1A1TP53MAPT | |
| SCHEMBL7305850 | 0.80 | PLAU (0.47) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7305935 | 0.78 | MTNR1A (0.43) | NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL7307064 | 0.73 | ITGB3 (0.74) | NPC1RAB9AALDH1A1TP53MAPT | |
| SCHEMBL7309377 | 0.73 | PLAU (0.47) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7308827 | 0.72 | LMNA (0.47) | MAPTSMN1; SMN2ITGB3ITGA2BF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709370-B1 | Bicyclic compounds useful as platelet aggregation inhibitors | MITSUI CHEMICALS INC (JP) | 1999-01-13 | — | — | EP | disclosed |
| US-5629321-A | FIBRINOGEN ANTAGONIST | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-13 | — | — | US | disclosed |
| EP-0709370-A1 | Bicyclic compounds useful as platelet aggregation inhibitors | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-05-01 | — | — | EP | disclosed |