Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 4/20 | 0.64 |
| ▸ | EGFR | P00533 | 3/20 | 0.64 |
| ▸ | IGF1R | P08069 | 1/20 | 0.64 |
| ▸ | CTRC | Q99895 | 1/20 | 0.59 |
| ▸ | DHFR | P00374 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 2/20 | 0.55 |
| ▸ | EEF2K | O00418 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7310712 | 1.00 | ERBB2 (0.64) | ERBB2EGFRIGF1RCTRCDHFR | |
| SCHEMBL7318433 | 0.85 | ERBB2 (0.68) | ERBB2EGFRIGF1RCTRCEEF2K | |
| SCHEMBL7318426 | 0.85 | ERBB2 (0.68) | ERBB2EGFRIGF1RCTRCEEF2K | |
| SCHEMBL6689435 | 0.84 | ERBB2 (0.67) | ERBB2EGFRIGF1RCTRCEEF2K | |
| SCHEMBL5472251 | 0.78 | ERBB2 (1.00) | ERBB2EGFRIGF1RCTRCDHFR | |
| SCHEMBL5472252 | 0.78 | ERBB2 (1.00) | ERBB2EGFRIGF1RCTRCDHFR | |
| SCHEMBL8324249 | 0.74 | CTRC (1.00) | ERBB2EGFRIGF1RCTRCEEF2K | |
| SCHEMBL7745840 | 0.74 | ERBB2 (0.57) | ERBB2EGFRIGF1RCTRCDHFR | |
| SCHEMBL13045105 | 0.73 | GAA (0.75) | ERBB2EGFRIGF1RCTRCEEF2K | |
| SCHEMBL5363945 | 0.73 | ERBB2 (0.58) | ERBB2EGFRIGF1RCTRCEEF2K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5124347-A | Inhibits 5-lipoxygenase and cyclooxygenase; for treatment of allergies, arthritis, pain | WARNER-LAMBERT CO. (US) | 1992-06-23 | — | — | US | claimed |
| US-6420428-B1 | TREATING HEPATITIS C AND HEPATIC FIBROSIS USING 2,6-DI-TERT-BUTYLPHENOL DERIVATIVES; EFFECTIVE IN SUBJECTS WITH INTERFERON INSUSCEPTIBILITY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-07-16 | — | — | US | disclosed |
| US-6369097-B1 | Treatment and prevention of hepatic disorders | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-04-09 | — | — | US | disclosed |
| US-6348493-B1 | TREATMENT OF HEPATITIS C BY ADMINISTERING 2,6-DI-TER-BUTYLPHENOL | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-02-19 | — | — | US | disclosed |
| US-6218437-B1 | ADMINISTERING A THERAPEUTIC AMOUNT OF DI-TERT-BUTYLPHENOL DERIVATIVE TO SUBJECT UNDER CONDITIONS SUCH THAT SAID SYMPTOMS ARE DIMINISHED | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2001-04-17 | — | — | US | disclosed |
| WO-2001021166-A1 | TREATMENT AND PREVENTION OF HEPATIC DISORDERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2001-03-29 | — | — | WO | disclosed |
| US-5124347-A | Inhibits 5-lipoxygenase and cyclooxygenase; for treatment of allergies, arthritis, pain | WARNER-LAMBERT CO. (US) | 1992-06-23 | — | — | US | disclosed |