Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 12/20 | 0.53 |
| ▸ | MMP1 | P03956 | 11/20 | 0.53 |
| ▸ | MMP2 | P08253 | 8/20 | 0.53 |
| ▸ | MMP14 | P50281 | 5/20 | 0.53 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.53 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.53 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 6/20 | 0.49 |
| ▸ | MMP9 | P14780 | 5/20 | 0.49 |
| ▸ | MMP16 | P51512 | 2/20 | 0.49 |
| ▸ | MMP3 | P08254 | 4/20 | 0.47 |
| ▸ | MMP12 | P39900 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7308712 | 0.78 | MMP13 (0.55) | MMP13MMP1MMP2MMP14MEP1B | |
| SCHEMBL8428266 | 0.73 | HTR2A (0.53) | MMP13MMP1MMP2MMP14MMP8 | |
| SCHEMBL5919644 | 0.72 | MMP1 (0.74) | MMP13MMP1MMP2MMP14ADAMTS4 | |
| SCHEMBL12020262 | 0.70 | MMP2 (0.69) | MMP13MMP1MMP2MMP14MMP8 | |
| SCHEMBL8596522 | 0.69 | MMP1 (0.47) | MMP13MMP1MMP2MMP14ADAMTS4 | |
| SCHEMBL7299271 | 0.69 | MMP1 (0.66) | MMP13MMP1MMP2MMP14ADAMTS4 | |
| SCHEMBL13873512 | 0.68 | HRH3 (0.63) | ALDH1A1 | |
| SCHEMBL7208001 | 0.67 | MMP13 (0.82) | MMP13MMP1MMP2MMP14ADAMTS4 | |
| SCHEMBL7307897 | 0.67 | MMP1 (1.00) | MMP13MMP1MMP2MMP14ADAMTS4 | |
| SCHEMBL4654488 | 0.67 | MMP1 (0.47) | MMP13MMP1MMP2MMP14ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |