Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 6/20 | 0.55 |
| ▸ | MMP1 | P03956 | 8/20 | 0.50 |
| ▸ | MMP8 | P22894 | 4/20 | 0.50 |
| ▸ | MMP2 | P08253 | 7/20 | 0.49 |
| ▸ | MMP9 | P14780 | 5/20 | 0.49 |
| ▸ | MMP3 | P08254 | 5/20 | 0.48 |
| ▸ | MEP1B | Q16820 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.45 |
| ▸ | ELOVL6 | Q9H5J4 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 3/20 | 0.44 |
| ▸ | MMP7 | P09237 | 2/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
| ▸ | MMP16 | P51512 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7310778 | 0.78 | MMP13 (0.53) | MMP13MMP1MMP8MMP2MMP9 | |
| SCHEMBL1188309 | 0.75 | MMP13 (0.73) | MMP13MMP1MMP8MMP2MMP9 | |
| SCHEMBL6932129 | 0.74 | MMP9 (0.59) | MMP13MMP1MMP8MMP2MMP9 | |
| SCHEMBL7442655 | 0.71 | MMP1 (0.57) | MMP13MMP1MMP8MMP2MMP9 | |
| SCHEMBL7510882 | 0.71 | MMP1 (0.57) | MMP13MMP1MMP8MMP2MMP9 | |
| SCHEMBL13043174 | 0.71 | MMP13 (0.63) | MMP13MMP1MMP8MMP2MMP9 | |
| SCHEMBL30748417 | 0.70 | MMP13 (0.60) | MMP13MMP1MMP8MMP2MMP9 | |
| SCHEMBL7529490 | 0.69 | MMP13 (0.55) | MMP13MMP1MMP8MMP2MMP9 | |
| SCHEMBL8438391 | 0.69 | MMP13 (0.74) | MMP13MMP1MMP8MMP2MMP9 | |
| SCHEMBL7698774 | 0.69 | MMP1 (0.54) | MMP13MMP1MMP8MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |