Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303017 | 0.93 | SIGMAR1 (0.39) | DRD3KDM4ESIGMAR1HTR7HRH2 | |
| SCHEMBL7297468 | 0.89 | DRD3 (0.41) | DRD3KDM4ESIGMAR1HTR7ALDH1A1 | |
| SCHEMBL7359856 | 0.87 | KDM4E (0.44) | DRD3KDM4ESIGMAR1HTR7ALDH1A1 | |
| SCHEMBL7301503 | 0.87 | HTR7 (0.43) | DRD3KDM4ESIGMAR1HTR7ALDH1A1 | |
| SCHEMBL7302447 | 0.87 | PARP1 (0.42) | DRD3KDM4ESIGMAR1HTR7ALDH1A1 | |
| SCHEMBL7298911 | 0.84 | ALDH1A1 (0.40) | DRD3KDM4ESIGMAR1HTR7HRH1 | |
| SCHEMBL7308008 | 0.83 | SIGMAR1 (0.42) | DRD3KDM4ESIGMAR1HTR7ALDH1A1 | |
| SCHEMBL7307713 | 0.82 | HTR7 (0.44) | DRD3KDM4ESIGMAR1HTR7ALDH1A1 | |
| SCHEMBL7310638 | 0.81 | KDM4E (0.43) | KDM4ESIGMAR1HTR7ALDH1A1MAPT | |
| SCHEMBL7307166 | 0.81 | KDM4E (0.43) | KDM4ESIGMAR1HTR7ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304560-A | Treating CNS disorders; dopamine receptor antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-19 | — | — | US | disclosed |
| CN-1060841-A | Quinazoline derivant and preparation method thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1992-05-06 | — | — | CN | disclosed |
| EP-0481342-A1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-22 | — | — | EP | disclosed |