Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 10/20 | 0.41 |
| ▸ | MMP14 | P50281 | 6/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 7/20 | 0.38 |
| ▸ | MMP2 | P08253 | 6/20 | 0.38 |
| ▸ | MMP3 | P08254 | 5/20 | 0.38 |
| ▸ | MMP9 | P14780 | 5/20 | 0.38 |
| ▸ | MMP8 | P22894 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | FNTB | P49356 | 1/20 | 0.36 |
| ▸ | MMP7 | P09237 | 2/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7298947 | 0.90 | MMP1 (0.47) | MMP1MMP14SRD5A2ALDH1A1MMP13 | |
| SCHEMBL7303599 | 0.88 | MMP1 (0.49) | MMP1MMP14ALDH1A1MMP13MMP2 | |
| SCHEMBL7312678 | 0.88 | MMP1 (0.43) | MMP1MMP14ALDH1A1MMP13MMP2 | |
| SCHEMBL7304251 | 0.88 | MMP1 (0.47) | MMP1MMP14ALDH1A1MMP13MMP2 | |
| SCHEMBL7304792 | 0.81 | MMP1 (0.60) | MMP1MMP14ALDH1A1MMP13MMP2 | |
| SCHEMBL7303726 | 0.78 | ALDH1A1 (0.44) | MMP1SRD5A2ALDH1A1MEN1KMT2A | |
| SCHEMBL7308395 | 0.77 | MMP1 (0.48) | MMP1MMP14MMP13MMP2MMP3 | |
| SCHEMBL7301981 | 0.77 | MMP1 (0.61) | MMP1MMP14MMP13MMP2MMP3 | |
| SCHEMBL7307399 | 0.76 | ALDH1A1 (0.43) | SRD5A2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL7307885 | 0.75 | PLA2G2A (0.36) | ALDH1A1LMNATSHRHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |