Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 15/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.44 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.43 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.43 |
| ▸ | ITGAL | P20701 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7309242 | 0.84 | REN (0.54) | RENEPHX2 | |
| SCHEMBL7318552 | 0.84 | MME (0.55) | RENITGB2ICAM1ITGAL | |
| SCHEMBL7311365 | 0.83 | LTA4H (0.44) | REN | |
| SCHEMBL7311328 | 0.83 | LTA4H (0.44) | REN | |
| SCHEMBL7311305 | 0.83 | LTA4H (0.44) | REN | |
| SCHEMBL7312785 | 0.77 | POLB (0.53) | — | |
| SCHEMBL8257707 | 0.74 | CPB2 (0.55) | RENEPHX2CPB2ITGB2ICAM1 | |
| SCHEMBL7307725 | 0.71 | MME (0.59) | RENITGB2ICAM1ITGAL | |
| SCHEMBL7322345 | 0.71 | MME (0.59) | RENITGB2ICAM1ITGAL | |
| SCHEMBL9828553 | 0.71 | EPHX2 (0.59) | RENEPHX2CPB2ITGB2ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459131-A | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1995-10-17 | — | — | US | disclosed |