Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 3/20 | 0.46 |
| ▸ | CTSS | P25774 | 3/20 | 0.46 |
| ▸ | CTSB | P07858 | 2/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
| ▸ | F3 | P13726 | 1/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10039872 | 1.00 | CTSL (0.46) | CTSLCTSSCTSBF2F10 | |
| SCHEMBL7309373 | 1.00 | CTSL (0.46) | CTSLCTSSCTSBF2F10 | |
| SCHEMBL10005610 | 1.00 | CTSL (0.46) | CTSLCTSSCTSBF2F10 | |
| SCHEMBL2116716 | 1.00 | CTSL (0.46) | CTSLCTSSCTSBF2F10 | |
| Hydroxyamine SCHEMBL7320373 | 0.98 | F2 (0.45) | CTSLCTSSCTSBF2F10 | |
| Hydroxyamine SCHEMBL7320378 | 0.98 | F2 (0.45) | CTSLCTSSCTSBF2F10 | |
| SCHEMBL9501192 | 0.93 | CTSL (0.46) | CTSLCTSSCTSBCA1CA2 | |
| SCHEMBL10363640 | 0.91 | TRPM8 (0.49) | CTSLCTSSCTSBF2F10 | |
| SCHEMBL9501314 | 0.91 | TRPM8 (0.49) | CTSLCTSSCTSBF2F10 | |
| SCHEMBL18857458 | 0.89 | CTSL (0.44) | CTSLCTSSCTSBMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4319040-A | Process for the production of optically active threo-3-(3,4-dihydroxyphenyl)serine | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1982-03-09 | — | — | US | claimed |
| EP-0024210-A1 | Process for the production of optically active threo-3-(3,4-dihydroxyphenyl) serine, and product thus produced | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1981-02-25 | — | — | EP | claimed |
| JP-56029551-A | — | — | None | — | — | JP | disclosed |
| US-11447443-B2 | Process for the preparation of droxidopa and its intermediate | PIRAMAL PHARMA LIMITED (IN) | 2022-09-20 | — | — | US | disclosed |
| US-11192848-B2 | Process for the preparation of droxidopa and its intermediate | PIRAMAL PHARMA LIMITED (IN) | 2021-12-07 | — | — | US | disclosed |
| US-20200354308-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF DROXIDOPA AND ITS INTERMEDIATE | Piramal Enterprises Limited (IN) | 2020-11-12 | — | — | US | disclosed |
| EP-3735403-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF DROXIDOPA AND ITS INTERMEDIATE | Piramal Enterprises Limited (IN) | 2020-11-11 | — | — | EP | disclosed |
| US-20200299227-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF DROXIDOPA AND ITS INTERMEDIATE | Piramal Enterprises Limited (IN) | 2020-09-24 | — | — | US | disclosed |
| WO-2019243087-A1 | ENZYMATIC PROCESS FOR THE PREPARATION OF DROXIDOPA | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2019-12-26 | — | — | WO | disclosed |
| WO-2019135189-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF DROXIDOPA AND ITS INTERMEDIATE | Piramal Enterprises Limited (IN) | 2019-07-11 | — | — | WO | disclosed |
| EP-3436426-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF DROXIDOPA AND ITS INTERMEDIATE | Piramal Enterprises Limited (IN) | 2019-02-06 | — | — | EP | disclosed |
| US-4699879-A | ENZYMIC DEACYLATION | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1987-10-13 | — | — | US | disclosed |
| EP-0177356-A2 | Method for treatment of antidiuresis | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1986-04-09 | — | — | EP | disclosed |
| EP-0141613-A2 | A process for producing an optically active 3-(3,4-dihydroxphenyl) serine and a proteced derivative thereof | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1985-05-15 | — | — | EP | disclosed |
| US-4319040-A | Process for the production of optically active threo-3-(3,4-dihydroxyphenyl)serine | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1982-03-09 | — | — | US | disclosed |
| US-4319040-A | Process for the production of optically active threo-3-(3,4-dihydroxyphenyl)serine | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1982-03-09 | — | — | US | disclosed |
| JP-S5629551-A | PREPARATION OF OPTICALLY ACTIVE THREO-3- 3,4- DIHYDROXYPHENYL SERINE | SUMITOMO CHEM CO LTD | 1981-03-24 | — | — | JP | disclosed |
| EP-0024210-A1 | Process for the production of optically active threo-3-(3,4-dihydroxyphenyl) serine, and product thus produced | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1981-02-25 | — | — | EP | disclosed |
| EP-0024210-A1 | Process for the production of optically active threo-3-(3,4-dihydroxyphenyl) serine, and product thus produced | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1981-02-25 | — | — | EP | disclosed |
| US-4246428-A | Method for separation of diastereoisomeric 3-(3,4-dibenzyloxyphenyl)serine | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1981-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11192848-B2 | Process for the preparation of droxidopa and its intermediate | COMT, DRD2, DAO | CTSL 1660/4885CTSS 1174/4885CTSB 1260/4885 |
| US-20200299227-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF DROXIDOPA AND ITS INTERMEDIATE | COMT, DAO, DDO | CTSL 1569/4885CTSS 1264/4885CTSB 1452/4885 |
| US-20200354308-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF DROXIDOPA AND ITS INTERMEDIATE | DAO, COMT, DRD4 | CTSL 1740/4885CTSS 1219/4885CTSB 1483/4885 |
| US-11447443-B2 | Process for the preparation of droxidopa and its intermediate | COMT, DAO, DRD4 | CTSL 1401/4885CTSS 1393/4885CTSB 1581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.