Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.53 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.49 |
| ▸ | TUBB | P07437 | 1/20 | 0.49 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.49 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.49 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.49 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.49 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.49 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.49 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.49 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.49 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.49 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.49 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.49 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.49 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7459854 | 0.85 | KDM4E (0.58) | KDM4ETDP1NR4A2ALOX5MAPT | |
| SCHEMBL9317997 | 0.85 | NR4A2 (0.69) | KDM4ENR4A2TUBB4ATUBBTUBA3C | |
| SCHEMBL3126546 | 0.82 | NR4A2 (0.51) | KDM4ETDP1NR4A2TUBB4ATUBB | |
| SCHEMBL3263777 | 0.79 | KDM4E (0.51) | KDM4ETDP1NR4A2ALOX5MAPT | |
| SCHEMBL8661193 | 0.78 | TUBB4A (0.64) | KDM4ETDP1TUBB4ATUBBTUBA3C | |
| SCHEMBL4625769 | 0.78 | KDM4E (0.51) | KDM4ETDP1NR4A2MAPTALDH1A1 | |
| SCHEMBL6583063 | 0.78 | TUBB4A (0.51) | KDM4ETDP1TUBB4ATUBBTUBA3C | |
| SCHEMBL3275504 | 0.77 | MEN1 (0.65) | KDM4ETDP1NR4A2TUBB4ATUBB | |
| SCHEMBL570154 | 0.77 | NR4A2 (0.67) | KDM4ETDP1NR4A2MAPTALDH1A1 | |
| SCHEMBL3264074 | 0.76 | KMT2A (0.53) | KDM4ETDP1NR4A2ALOX5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4845092-A | OF VISCERAL PAIN IN MAMMALS, HUMANS | BEECHAM GROUP PLC (GB) | 1989-07-04 | — | — | US | claimed |
| US-4789673-A | ANTISEROTONINE AGENTS | NOVARTIS AG (CH) | 1988-12-06 | — | — | US | claimed |
| EP-0279512-A2 | Use of certain 5-HT3 receptor antagonists in the treatment of visceral pain | BEECHAM GROUP PLC (GB) | 1988-08-24 | — | — | EP | claimed |
| US-4845092-A | OF VISCERAL PAIN IN MAMMALS, HUMANS | BEECHAM GROUP PLC (GB) | 1989-07-04 | — | — | US | disclosed |
| US-4789673-A | ANTISEROTONINE AGENTS | NOVARTIS AG (CH) | 1988-12-06 | — | — | US | disclosed |
| EP-0279512-A2 | Use of certain 5-HT3 receptor antagonists in the treatment of visceral pain | BEECHAM GROUP PLC (GB) | 1988-08-24 | — | — | EP | disclosed |