Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.36 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.36 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.36 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.36 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.36 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.36 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.36 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7311575 | 1.00 | MAPK1 (0.44) | MAPK1MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL7301913 | 0.91 | POLB (0.40) | POLBALDH1A1EIF4HLMNASMN1; SMN2 | |
| SCHEMBL8887447 | 0.91 | POLB (0.40) | POLBALDH1A1EIF4HLMNASMN1; SMN2 | |
| SCHEMBL7311572 | 0.89 | MAPK1 (0.40) | MAPK1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL7313668 | 0.86 | SMN1; SMN2 (0.45) | MAPK1MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL7308007 | 0.86 | SMN1; SMN2 (0.45) | MAPK1MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL7301807 | 0.85 | CTSK (0.45) | PSMB5 | |
| SCHEMBL7301786 | 0.85 | CTSK (0.45) | PSMB5 | |
| Hydrochloric Acid SCHEMBL7308810 | 0.84 | CTSL (0.42) | MAPK1POLBALDH1A1EIF4HLMNA | |
| Hydrochloric Acid SCHEMBL7308817 | 0.84 | CTSL (0.42) | MAPK1POLBALDH1A1EIF4HLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525420-B1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | MITSUBISHI CHEM CORP (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5834508-A | PROTEASE ENZYME INHIBITORS; MUSCLE DISORDERS | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-11-10 | — | — | US | disclosed |
| US-5639783-A | POTENT PROTEASE INHIBITOR FOR TREATING MUSCULAR, NERVOUS SYSTEM DISEASES | MITSUBISHI CHEMICAL CORPORATION (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0525420-A1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | Mitsubishi Chemical Corporation (JP) | 1993-02-03 | — | — | EP | disclosed |