Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7308007 | 1.00 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1HPGDMAPK1MAPT | |
| Hydrochloric Acid SCHEMBL7308817 | 0.91 | CTSL (0.42) | SMN1; SMN2ALDH1A1HPGDMAPK1MAPT | |
| Hydrochloric Acid SCHEMBL7308810 | 0.91 | CTSL (0.42) | SMN1; SMN2ALDH1A1HPGDMAPK1MAPT | |
| SCHEMBL8887447 | 0.90 | POLB (0.40) | SMN1; SMN2ALDH1A1HPGDMAPTPSMB5 | |
| SCHEMBL7301913 | 0.90 | POLB (0.40) | SMN1; SMN2ALDH1A1HPGDMAPTPSMB5 | |
| SCHEMBL7313664 | 0.88 | ALDH1A1 (0.42) | SMN1; SMN2ALDH1A1HPGDMAPK1MAPT | |
| SCHEMBL7310572 | 0.86 | CTSK (0.43) | SMN1; SMN2ALDH1A1HPGDPSEN1PSEN2 | |
| SCHEMBL7306659 | 0.86 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1HPGDMAPTPSMB5 | |
| SCHEMBL8886883 | 0.86 | CTSK (0.43) | SMN1; SMN2ALDH1A1HPGDPSEN1PSEN2 | |
| SCHEMBL7433853 | 0.86 | CTSK (0.43) | SMN1; SMN2ALDH1A1HPGDPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525420-B1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | MITSUBISHI CHEM CORP (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5834508-A | PROTEASE ENZYME INHIBITORS; MUSCLE DISORDERS | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-11-10 | — | — | US | disclosed |
| US-5639783-A | POTENT PROTEASE INHIBITOR FOR TREATING MUSCULAR, NERVOUS SYSTEM DISEASES | MITSUBISHI CHEMICAL CORPORATION (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0525420-A1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | Mitsubishi Chemical Corporation (JP) | 1993-02-03 | — | — | EP | disclosed |