Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 7/20 | 0.53 |
| ▸ | TAS1R1 | Q7RTX1 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 3/20 | 0.40 |
| ▸ | NOS1 | P29475 | 3/20 | 0.40 |
| ▸ | NOS2 | P35228 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7311611 | 1.00 | TAS1R3 (0.53) | TAS1R3TAS1R1ALDH1A1MAPTHPGD | |
| SCHEMBL7311608 | 1.00 | TAS1R3 (0.53) | TAS1R3TAS1R1ALDH1A1MAPTHPGD | |
| SCHEMBL7311615 | 0.88 | ALDH1A1 (0.53) | TAS1R3TAS1R1ALDH1A1MAPTHPGD | |
| SCHEMBL7300813 | 0.87 | CTSS (0.44) | TAS1R3TAS1R1ALDH1A1MAPTHPGD | |
| SCHEMBL7300831 | 0.87 | CTSS (0.44) | TAS1R3TAS1R1ALDH1A1MAPTHPGD | |
| SCHEMBL7306949 | 0.85 | HPGD (0.42) | ALDH1A1MAPTHPGDRECQLSMN1; SMN2 | |
| SCHEMBL7431367 | 0.85 | HPGD (0.42) | ALDH1A1MAPTHPGDRECQLSMN1; SMN2 | |
| SCHEMBL7306399 | 0.83 | POLB (0.50) | TAS1R3TAS1R1ALDH1A1MAPTHPGD | |
| SCHEMBL7306413 | 0.83 | POLB (0.50) | TAS1R3TAS1R1ALDH1A1MAPTHPGD | |
| SCHEMBL7438981 | 0.81 | POLB (0.40) | ALDH1A1MAPTHPGDRECQLSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525420-B1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | MITSUBISHI CHEM CORP (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5639783-A | POTENT PROTEASE INHIBITOR FOR TREATING MUSCULAR, NERVOUS SYSTEM DISEASES | MITSUBISHI CHEMICAL CORPORATION (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0525420-A1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | Mitsubishi Chemical Corporation (JP) | 1993-02-03 | — | — | EP | disclosed |